Rabbit LIN7C Polyclonal Antibody | anti-LIN7C antibody

LIN7C Antibody

Cat. Num. AAA9611880

• Gene Names: LIN7C; MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: LIN7C; Polyclonal Antibody; LIN7C Antibody; LIN 7 C; Lin 7 homolog C (C. elegans); LIN 7 protein 3; LIN 7C; LIN7 protein 3; MALS 3; MALS3; Mammalian lin seven protein 3; Protein lin 7 homolog C; Veli 3; Veli 3 protein; VELI3; Vertebrate lin 7 homolog 3; anti-LIN7C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: LIN7C Antibody detects endogenous levels of LIN7C.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 197

• Applicable Applications for anti-LIN7C antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human LIN7C.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Plasma Membrane
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, using LIN7C Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-LIN7C antibody

Description: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Subunit Structure: Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with MAPK12 (By similarity).

Similarity: The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane. The PDZ domain regulates endocytosis and recycling of the receptor at the membrane. The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes. Belongs to the lin-7 family.

NCBI and Uniprot Product Information

• NCBI GI #: 8922944
• NCBI GeneID: 55327
• NCBI Accession #: NP_060832.1
• NCBI GenBank Nucleotide #: NP_060832.1
• UniProt Accession #: Q9NUP9
• Molecular Weight: Observed: 25 kDa; Predicted: 22 kDa
• NCBI Official Full Name: protein lin-7 homolog C
• NCBI Official Synonym Full Names: lin-7 homolog C, crumbs cell polarity complex component
• NCBI Official Symbol: LIN7C
• NCBI Official Synonym Symbols: MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• NCBI Protein Information: protein lin-7 homolog C
• UniProt Protein Name: Protein lin-7 homolog C
• Protein Family: Protein
• UniProt Gene Name: LIN7C
• UniProt Synonym Gene Names: MALS3; VELI3; Lin-7C; MALS-3; Veli-3
• UniProt Entry Name: LIN7C_HUMAN

Uniprot Description

LIN7C: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11p14

Cellular Component: postsynaptic membrane; neuron projection; tight junction; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; synapse; intercellular junction

Molecular Function: protein domain specific binding; cytoskeletal protein binding; PDZ domain binding

Biological Process: asymmetric protein localization; protein transport; exocytosis; neurotransmitter secretion; morphogenesis of an epithelial sheet; maintenance of epithelial cell polarity