Rabbit anti-Human LIN7C Polyclonal Antibody | anti-LIN7C antibody

LIN7C, CT (LIN7C, MALS3, VELI3, Protein lin-7 homolog C, Mammalian lin-seven protein 3, Vertebrate lin-7 homolog 3) (PE)

Cat. Num. AAA6316305

• Gene Names: LIN7C; MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LIN7C; Polyclonal Antibody; CT (LIN7C; MALS3; VELI3; Protein lin-7 homolog C; Mammalian lin-seven protein 3; Vertebrate lin-7 homolog 3) (PE); Vertebrate lin-7 homolog 3; anti-LIN7C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-LIN7C antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: LIN7C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-197 amino acids from the C-terminal region of human LIN7C.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Immunohistochemistry (IHC)

(LIN7C Antibdy (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LIN7C Antibdy (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Western Blot (WB)

(LIN7C Antibody (C-term) western blot analysis in MCF-7,NCI-H292 cell line lysates (35ug/lane).This demonstrates the LIN7C antibody detected the LIN7C protein (arrow).)

Related Product Information for anti-LIN7C antibody

LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Product Categories/Family for anti-LIN7C antibody

Antibodies; Proteins

References

Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010). Lanktree, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 945-951 (2008): Bulgin, N.L., et al. Neuromolecular Med. 10(4):343-355(2008). Onda, T., et al. Cancer Res. 67(20):9643-9648(2007). Bohl, J., et al. J. Biol. Chem. 282(13):9392-9400(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 8922944
• NCBI GeneID: 55327
• NCBI Accession #: NP_060832.1
• NCBI GenBank Nucleotide #: NM_018362.3
• UniProt Accession #: Q9NUP9
• Molecular Weight: 21,834 Da
• NCBI Official Full Name: protein lin-7 homolog C
• NCBI Official Synonym Full Names: lin-7 homolog C (C. elegans)
• NCBI Official Symbol: LIN7C
• NCBI Official Synonym Symbols: MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
• NCBI Protein Information: protein lin-7 homolog C; LIN-7 protein 3; mammalian lin-seven protein 3; veli-3; vertebrate lin-7 homolog 3
• UniProt Protein Name: Protein lin-7 homolog C
• Protein Family: Protein
• UniProt Gene Name: LIN7C
• UniProt Synonym Gene Names: MALS3; VELI3; Lin-7C; MALS-3; Veli-3
• UniProt Entry Name: LIN7C_HUMAN

Uniprot Description

LIN7C: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11p14

Cellular Component: postsynaptic membrane; neuron projection; tight junction; basolateral plasma membrane; cytoplasm; postsynaptic density; plasma membrane; synapse; intercellular junction

Molecular Function: protein domain specific binding; cytoskeletal protein binding; PDZ domain binding

Biological Process: asymmetric protein localization; protein transport; exocytosis; neurotransmitter secretion; morphogenesis of an epithelial sheet; maintenance of epithelial cell polarity