Immunohistochemistry (IHC)
(Anti-HIPK3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Rabbit HIPK3 / FIST Polyclonal Antibody | anti-HIPK3 antibody
Rabbit Polyclonal to Human HIPK3 / FIST
Gene Names
HIPK3; PKY; YAK1; DYRK6; FIST3
Reactivity
Chimpanzee, Dog, Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunoaffinity Purified
Synonyms
HIPK3 / FIST; Polyclonal Antibody; Rabbit Polyclonal to Human HIPK3 / FIST; Anti-HIPK3 / FIST Antibody (aa850-900) IHC-plus; HIPK3; ANPK; FIST; FIST3; Homolog of protein kinase YAK1; DYRK6; PKY; YAK1; Human HIPK3; anti-HIPK3 antibody
Host
Rabbit
Reactivity
Chimpanzee, Dog, Human, Mouse, Rat
Clonality
Polyclonal
Specificity
A portion of amino acids 850-900 of human HIPK3
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.2% gelatin, 0.05% sodium azide.
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
1215
Applicable Applications for anti-HIPK3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes
IHC-P (10 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Target Species
Human
Immunogen Description
Synthetic peptide from human HIPK3.
Immunogen Type
Synthetic peptide
Immunogen
HIPK3 / FIST antibody was raised against synthetic peptide from human HIPK3.
Antigen Modification
aa850-900
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Immunohistochemistry (IHC)
(Anti-HIPK3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Immunohistochemistry (IHC)
(Anti-HIPK3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Western Blot (WB)
(Western blot of HIPK3 inumouse testis lysate in the 1) absence, 2) presence of immunizing peptide and 3)?rat testis using antibody at 1 ug/ml.)
Western Blot (WB)
(Western blot of HIPK3 inumouse testis lysate in the 1) absence, 2) presence of immunizing peptide and 3)?rat testis using antibody at 1 ug/ml.)
Related Product Information for anti-HIPK3 antibody
HIPK3, a nuclear serine/threonine kinase similar to the MNB/DYRK type protein kinases. HIPK3 may be involved in growth control pathways and in multidrug resistance. HIPK3 interacts with Fas and FADD and modulates FasL-induced JNK activation.
Product Categories/Family for anti-HIPK3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
131,256 Da
NCBI Official Full Name
homeodomain-interacting protein kinase 3 isoform 1
NCBI Official Synonym Full Names
homeodomain interacting protein kinase 3
NCBI Official Symbol
HIPK3
NCBI Official Synonym Symbols
PKY; YAK1; DYRK6; FIST3
NCBI Protein Information
homeodomain-interacting protein kinase 3; ANPK; FIST; homolog of protein kinase YAK1; fas-interacting serine/threonine-protein kinase; androgen receptor-interacting nuclear protein kinase
UniProt Protein Name
Homeodomain-interacting protein kinase 3
Protein Family
UniProt Gene Name
HIPK3
UniProt Synonym Gene Names
DYRK6; FIST3; PKY; ANPK; FIST
UniProt Entry Name
HIPK3_HUMAN
Uniprot Description
HIPK3: homeodomain interacting protein kinase 3 is a CMGC kinase of the DYRK family. Phosphorylates FADD and inhibits fas-mediated Jun NH(2)-terminal kinase activation.
Protein type: Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; EC 2.7.11.1; CMGC group; DYRK family; HIPK subfamily
Chromosomal Location of Human Ortholog: 11p13
Cellular Component: PML body; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity
Biological Process: negative regulation of JNK activity; peptidyl-serine phosphorylation; regulation of transcription, DNA-dependent; apoptosis; peptidyl-threonine phosphorylation; mRNA transcription; protein amino acid phosphorylation; negative regulation of apoptosis
Research Articles on HIPK3
Similar Products
Product Notes
The HIPK3 hipk3 (Catalog #AAA241696) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human HIPK3 / FIST reacts with Chimpanzee, Dog, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HIPK3 / FIST can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (10 ug/ml), WB (0.5 - 2 ug/ml) Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the HIPK3 hipk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HIPK3 / FIST, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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