Rabbit anti-Human LIN7A Polyclonal Antibody | anti-LIN7A antibody

LIN7A, CT (LIN7A, MALS1, VELI1, Protein lin-7 homolog A, Mammalian lin-seven protein 1, Tax interaction protein 33, Vertebrate lin-7 homolog 1) (AP)

Cat. Num. AAA6316273

• Gene Names: LIN7A; LIN7; VELI1; LIN-7A; MALS-1; TIP-33
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LIN7A; Polyclonal Antibody; CT (LIN7A; MALS1; VELI1; Protein lin-7 homolog A; Mammalian lin-seven protein 1; Tax interaction protein 33; Vertebrate lin-7 homolog 1) (AP); Vertebrate lin-7 homolog 1; anti-LIN7A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-LIN7A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: LIN7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-207 amino acids from the C-terminal region of human LIN7A.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(LIN7A Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the LIN7A antibody detected the LIN7A protein (arrow).)

Related Product Information for anti-LIN7A antibody

LIN7A plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Product Categories/Family for anti-LIN7A antibody

Antibodies; Proteins

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Lanktree, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 945-951 (2008): Bohl, J., et al. J. Biol. Chem. 282(13):9392-9400(2007). Dode, L., et al. J. Biol. Chem. 280(47):39124-39134(2005). Olsen, O., et al. Am. J. Physiol. Renal Physiol. 288 (2), F345-F352 (2005).

NCBI and Uniprot Product Information

• NCBI GI #: 4759306
• NCBI GeneID: 8825
• NCBI Accession #: NP_004655.1
• NCBI GenBank Nucleotide #: NM_004664.2
• UniProt Accession #: O14910; Q147W1; Q6LES3; Q7LDS4; A4FTY3
• Molecular Weight: 25,997 Da
• NCBI Official Full Name: protein lin-7 homolog A
• NCBI Official Synonym Full Names: lin-7 homolog A (C. elegans)
• NCBI Official Symbol: LIN7A
• NCBI Official Synonym Symbols: LIN7; VELI1; LIN-7A; MALS-1; TIP-33
• NCBI Protein Information: protein lin-7 homolog A; hLin-7; mammalian LIN-7 1; mammalian lin-seven protein 1; tax interaction protein 33; veli-1; vertebrate LIN7 homolog 1; vertebrate lin-7 homolog 1
• UniProt Protein Name: Protein lin-7 homolog A
• Protein Family: Protein
• UniProt Gene Name: LIN7A
• UniProt Synonym Gene Names: MALS1; VELI1; Lin-7A; hLin-7; MALS-1; TIP-33; Veli-1
• UniProt Entry Name: LIN7A_HUMAN

Uniprot Description

LIN7A: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.

Protein type: Adaptor/scaffold; Cell adhesion

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: postsynaptic membrane; neuron projection; tight junction; basolateral plasma membrane; postsynaptic density; synapse; intercellular junction

Molecular Function: protein binding; PDZ domain binding

Biological Process: asymmetric protein localization; protein transport; exocytosis; neurotransmitter secretion; synaptic vesicle transport; protein complex assembly; inner ear development; maintenance of epithelial cell polarity