Rabbit anti-Human, Mouse LDB1 Polyclonal Antibody | anti-LDB1 antibody

LDB1 Polyclonal Antibody

Cat. Num. AAA2560897

• Gene Names: LDB1; NLI; CLIM2; LDB-1; CLIM-2
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: LDB1; Polyclonal Antibody; LDB1 Polyclonal Antibody; Carboxyl Terminal LIM Domain Binding 2; Carboxyl-terminal LIM domain-binding protein 2; CLIM 2; CLIM-2; HLdb1; LDB-1; Ldb1; LIM Domain Binding 1; LIM domain binding factor CLIM2; LIM domain-binding factor CLIM2; LIM domain-binding protein 1; NLI; Nuclear LIM Domain Interactor; Nuclear LIM interactor; Xldb1; anti-LDB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.2mg/mL (varies by lot)
• Sequence Length: 411

• Applicable Applications for anti-LDB1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:70-1:350; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human LDB1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using LDB1 Polyclonal Antibody at dilution of 1:70(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using LDB1 Polyclonal Antibody at dilution of 1:70(×200))

Related Product Information for anti-LDB1 antibody

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).

Product Categories/Family for anti-LDB1 antibody

Cancer; Epigenetics and Nuclear Signaling; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 164663816
• NCBI GeneID: 8861
• NCBI Accession #: NP_001106878.1; BC000482
• NCBI GenBank Nucleotide #: NP_001106878.1
• UniProt Accession #: Q86U70
• NCBI Official Full Name: LIM domain-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: LIM domain binding 1
• NCBI Official Symbol: LDB1
• NCBI Official Synonym Symbols: NLI; CLIM2; LDB-1; CLIM-2
• NCBI Protein Information: LIM domain-binding protein 1
• UniProt Protein Name: LIM domain-binding protein 1
• Protein Family: LIM domain-binding protein
• UniProt Gene Name: LDB1
• UniProt Synonym Gene Names: CLIM2; LDB-1; CLIM-2; hLdb1
• UniProt Entry Name: LDB1_HUMAN

Uniprot Description

LDB1: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Belongs to the LDB family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10q24-q25

Cellular Component: transcription factor complex; protein complex; nuclear chromatin; nucleus

Molecular Function: LIM domain binding; enzyme binding; protein homodimerization activity; protein self-association; chromatin binding; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of erythrocyte differentiation; positive regulation of cell adhesion; Wnt receptor signaling pathway; transcription, DNA-dependent; somatic stem cell maintenance; multicellular organismal development; gastrulation with mouth forming second; positive regulation of hemoglobin biosynthetic process; cellular component assembly; neuron differentiation; regulation of transcription, DNA-dependent; hair follicle development; cerebellar Purkinje cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of RNA elongation; anterior/posterior axis specification