Western Blot (WB)
(LAT2 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LAT2 antibody detected the LAT2 protein (arrow).)
Rabbit anti-Human LAT2 Polyclonal Antibody | anti-LAT2 antibody
LAT2, ID (LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5, Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 prote
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(LAT2 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LAT2 antibody detected the LAT2 protein (arrow).)
Western Blot (WB)
(LAT2 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LAT2 antibody detected the LAT2 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. Ref.3 Ref.4 Ref.11
Subunit structure: When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL. Ref.3 Ref.4 Ref.12
Subcellular location: Cell membrane; Single-pass type III membrane protein. Note: Present in lipid rafts. Ref.3 Ref.4
Tissue specificity: Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level). Ref.1 Ref.3 Ref.4 Ref.13
Post-translational modification: Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2. Ref.3 Ref.4 Ref.12May be polyubiquitinated.
Involvement in disease: LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Ref.1 Ref.2 Ref.5
Sequence caution: The sequence AAF29018.1 differs from that shown. Reason: Frameshift at positions 82, 86, 130 and 221.
Research Articles on LAT2
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Product Notes
The LAT2 lat2 (Catalog #AAA648331) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LAT2, ID (LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5, Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 prote reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LAT2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the LAT2 lat2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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