Western Blot (WB)
(Western Blot analysis of LARP6 expression in transfected 293T cell line by LARP6 polyclonal antibody. Lane 1: LARP6 transfected lysate (54.01kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human LARP6 Polyclonal Antibody | anti-LARP6 antibody
LARP6 (La-related Protein 6, Acheron, La Ribonucleoprotein Domain Family Member 6, FLJ11196)
Gene Names
LARP6; ACHN
Reactivity
Human
Applications
Western Blot, Immunofluorescence
Purity
Affinity PurifiedPurified by Protein A affinity chromatography.
Synonyms
LARP6; Polyclonal Antibody; LARP6 (La-related Protein 6; Acheron; La Ribonucleoprotein Domain Family Member 6; FLJ11196); Anti -LARP6 (La-related Protein 6; anti-LARP6 antibody
Host
Mouse
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human LARP6.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Sequence
MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKPAKDKNHDEEPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNKLSPSGHQNLFLSPNASPCTSPWSSPLAQRKGVSRKSPLAEEGRLNCSTSPEIFRKCMDYSSDSSVTPSGSPWVRRRRQAEMGTQEKSPGTSPLLSRKMQTADGLPVGVLRLPRGPDNTRGFHGHERSRACV
Applicable Applications for anti-LARP6 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml
Dilution: Immunofluorescence: 10ug/ml
Immunogen
Full length human LARP6, aa1-491 (NP_060827).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of LARP6 expression in transfected 293T cell line by LARP6 polyclonal antibody. Lane 1: LARP6 transfected lysate (54.01kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of LARP6 expression in transfected 293T cell line by LARP6 polyclonal antibody. Lane 1: LARP6 transfected lysate (54.01kD). Lane 2: Non-transfected lysate.)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to LARP6 on HeLa cell. [antibody concentration 10ug/ml].)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to LARP6 on HeLa cell. [antibody concentration 10ug/ml].)
Related Product Information for anti-LARP6 antibody
LARP6 is a member of the La ribonucleoprotein domain family, which all contain one characteristic La motif. LARP6 shuttles between the cytoplasm and nucleus. It is proposed that members of this family play a role in translation and mRNA stability.
Product Categories/Family for anti-LARP6 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
54,737 Da
NCBI Official Full Name
la-related protein 6 isoform 2
NCBI Official Synonym Full Names
La ribonucleoprotein domain family, member 6
NCBI Official Symbol
LARP6
NCBI Official Synonym Symbols
ACHN
NCBI Protein Information
la-related protein 6; acheron; death-associated LA motif protein
UniProt Protein Name
La-related protein 6
Protein Family
UniProt Gene Name
LARP6
UniProt Synonym Gene Names
Achn
UniProt Entry Name
LARP6_HUMAN
Uniprot Description
Function: Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. Ref.7 Ref.8 Ref.9
Subunit structure: Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9. Ref.7 Ref.8 Ref.9
Subcellular location: Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Ref.1
Tissue specificity: Expressed in numerous tissues. Ref.1
Domain: The RRM domain mediates the association with collagen mRNAs stem-loops.
Sequence similarities: Contains 1 HTH La-type RNA-binding domain.Contains 1 RRM (RNA recognition motif) domain.
Research Articles on LARP6
Similar Products
Product Notes
The LARP6 larp6 (Catalog #AAA648231) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The LARP6 (La-related Protein 6, Acheron, La Ribonucleoprotein Domain Family Member 6, FLJ11196) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LARP6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the LARP6 larp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V. It is sometimes possible for the material contained within the vial of "LARP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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