Rabbit BACE2 Polyclonal Antibody | anti-BACE2 antibody

Rabbit Polyclonal to Human BACE2

Cat. Num. AAA243362

• Gene Names: BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: BACE2; Polyclonal Antibody; Rabbit Polyclonal to Human BACE2; Anti-BACE2 Antibody (aa44-59) IHC-plus; 56 kDa aspartic-like protease; AEPLC; ALP56; Aspartic-like protease 56 kDa; APL56; BAE2; Beta-secretase 2; ASP21; CDA13; DRAP; Memapsin-1; Asp 1; ASP1; Aspartyl protease 1; Theta-secretase; Beta secretase 2; CEAP1; Down region aspartic protease; Human BACE2; anti-BACE2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: synthetic peptide (aptpgpgtpaerhadg) corresponding to amino acids 44 to 59 of human BACE2
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 518

• Applicable Applications for anti-BACE2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human BACE2.
• Immunogen Type: Synthetic peptide
• Immunogen: BACE2 antibody was raised against synthetic peptide from human BACE2.
• Antigen Modification: aa44-59
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-BACE2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-BACE2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of BACE2 in human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1 ug/ml.)

Product Categories/Family for anti-BACE2 antibody

Family: Protease; Subfamily: Aspartic A1

NCBI and Uniprot Product Information

• NCBI GI #: 19923395
• NCBI GeneID: 25825
• NCBI Accession #: NP_036237.2
• NCBI GenBank Nucleotide #: NM_012105.4
• UniProt Accession #: Q9Y5Z0; Q5DIH8; Q8N2D4; Q9H2V8; Q9NZL1; Q9NZL2; Q9UJT6; A8K7P1
• Molecular Weight: 46,476 Da
• NCBI Official Full Name: beta-secretase 2 isoform A preproprotein
• NCBI Official Synonym Full Names: beta-site APP-cleaving enzyme 2
• NCBI Official Symbol: BACE2
• NCBI Official Synonym Symbols: ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1
• NCBI Protein Information: beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
• UniProt Protein Name: Beta-secretase 2
• Protein Family: Beta-secretase
• UniProt Gene Name: BACE2
• UniProt Synonym Gene Names: AEPLC; ALP56; ASP21; ASP1; Asp 1; Beta-site APP cleaving enzyme 2; DRAP
• UniProt Entry Name: BACE2_HUMAN

NCBI Description

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.4.23.45; Protease

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to membrane; endosome

Molecular Function: aspartic-type endopeptidase activity

Biological Process: negative regulation of amyloid precursor protein biosynthetic process; peptide hormone processing; membrane protein ectodomain proteolysis; proteolysis