Rabbit anti-Human L3MBTL Polyclonal Antibody | anti-L3MBTL antibody

L3MBTL antibody

Cat. Num. AAA9406434

• Gene Names: L3MBTL1; L3MBTL; ZC2HC3; H-L(3)MBT; dJ138B7.3
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: L3MBTL; Polyclonal Antibody; L3MBTL antibody; anti-L3MBTL antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
• Sequence Length: 772

• Applicable Applications for anti-L3MBTL antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500-1:3000; Immunofluorescence: 1:100-1:200
• Immunogen Type: Recombinant protein
• Immunogen Description: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 365 and 723 of L3MBTL
• Target Name: L3MBTL
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Testing Data

(Sample(30 ug whole cell lysate)A: HeLa S37.5% SDS PAGEPrimary antibody diluted at 1: 1000)

Immunofluorescence (IF)

(Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using L3MBTL antibody at 1: 200 dilution.)

Related Product Information for anti-L3MBTL antibody

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Product Categories/Family for anti-L3MBTL antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 117938328
• NCBI GeneID: 26013
• NCBI Accession #: NP_056293
• NCBI GenBank Nucleotide #: NM_015478.6
• Molecular Weight: 92,297 Da
• NCBI Official Full Name: lethal(3)malignant brain tumor-like protein 1 isoform I
• NCBI Official Synonym Full Names: l(3)mbt-like 1 (Drosophila)
• NCBI Official Symbol: L3MBTL1
• NCBI Official Synonym Symbols: L3MBTL; ZC2HC3; H-L(3)MBT; dJ138B7.3
• NCBI Protein Information: lethal(3)malignant brain tumor-like protein 1
• UniProt Protein Name: Lethal(3)malignant brain tumor-like protein 1
• UniProt Gene Name: L3MBTL1
• UniProt Synonym Gene Names: KIAA0681; L3MBT; L3MBTL; H-l(3)mbt; H-l(3)mbt protein; L(3)mbt-like
• UniProt Entry Name: LMBL1_HUMAN

NCBI Description

This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Uniprot Description

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.