Testing Data
Rabbit anti-Human L3MBTL1 Polyclonal Antibody | anti-L3MBTL1 antibody
L3MBTL1 polyclonal antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
Background: L3MBTL1 is a member of the polycomb group (PcG) proteins, which function as transcriptional regulators in large protein complexes. In Drosophila, homozygous mutations in the L3MBTL1 gene have been demonstrated to cause brain tumors, identifying L3MBTL1 as a tumor suppressor gene. L3MBTL1 forms a homodimer and interacts with TEL (ETV6). L3MBTL1 probably plays a role in cell proliferation. Overexpression of L3MBTL1 induces multinucleated cells, suggesting that it is required for normal mitosis.
NCBI and Uniprot Product Information
NCBI Description
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Uniprot Description
L3MBTL: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Histone-binding
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: nucleoplasm; nucleolus; plasma membrane; condensed chromosome; nucleus; chromatin
Molecular Function: identical protein binding; protein binding; nucleosomal histone binding; zinc ion binding; histone binding; nucleosome binding; SAM domain binding; chromatin binding; transcription factor activity; methylated histone residue binding
Biological Process: transcription, DNA-dependent; regulation of cell cycle; regulation of megakaryocyte differentiation; regulation of mitosis; hemopoiesis; chromatin modification; negative regulation of transcription, DNA-dependent
Research Articles on L3MBTL1
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Product Notes
The L3MBTL1 l3mbtl1 (Catalog #AAA841214) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The L3MBTL1 polyclonal antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's L3MBTL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Western Blot: 1:1000, IP: 1 - 5 ug/IP. Researchers should empirically determine the suitability of the L3MBTL1 l3mbtl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "L3MBTL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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