Rabbit Kv7.1 Polyclonal Antibody | anti-Kv7.1 antibody

Kv7.1 Polyclonal Antibody

Cat. Num. AAA3006462

• Gene Names: KCNQ1; LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Kv7.1; Polyclonal Antibody; Kv7.1 Polyclonal Antibody; Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1; KCNQ1; KCNA8; KCNA9; KVLQT1; anti-Kv7.1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Kv7.1 polyclonal antibody detects endogenous levels of Kv7.1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 676

• Applicable Applications for anti-Kv7.1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human Kv7.1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Kv7. 1 polyclonal antibody at 1:500 dilutionLane1:DLD whole cell lysateLane2:Mouse brain tissue lysateLane3:Rat brain tissue lysate)

Related Product Information for anti-Kv7.1 antibody

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

NCBI and Uniprot Product Information

• NCBI GI #: 32479527
• NCBI GeneID: 3784
• NCBI Accession #: NP_000209.2
• NCBI GenBank Nucleotide #: NP_000209.2
• UniProt Accession #: P51787
• Molecular Weight: ~ 75kDa
• NCBI Official Full Name: potassium voltage-gated channel subfamily KQT member 1 isoform 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily Q member 1
• NCBI Official Symbol: KCNQ1
• NCBI Official Synonym Symbols: LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 1
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 1
• UniProt Gene Name: KCNQ1
• UniProt Synonym Gene Names: KCNA8; KCNA9; KVLQT1
• UniProt Entry Name: KCNQ1_HUMAN

NCBI Description

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]