Human Prokineticin-1 ELISA Kit | PROK1 elisa kit

Human Prokineticin-1 ELISA Kit

Cat. Num. AAA2887495

• Gene Names: PROK1; PK1; PRK1; EGVEGF
• Reactivity: Human
• Synonyms: Prokineticin-1; Human Prokineticin-1 ELISA Kit; Endocrine-gland-derived vascular endothelial growth factor; EG-VEGF; Mambakine; PROK1; UNQ600/PRO1186; PROK1 elisa kit

• Reactivity: Human
• Sequence Length: 105

• Assay Type: Sandwich
• Detection Range: 7.8-500 pg/mL
• Sensitivity: 2.1 pg/mL
• Intra-Assay CV: <=6.8%
• Inter-Assay CV: <=9.7%
• Recovery: 99%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 14165282
• NCBI GeneID: 84432
• NCBI Accession #: NP_115790.1
• NCBI GenBank Nucleotide #: NM_032414.2
• UniProt Accession #: P58294; Q5VWD4; Q8TC69
• Molecular Weight: 11,715 Da
• NCBI Official Full Name: prokineticin-1
• NCBI Official Synonym Full Names: prokineticin 1
• NCBI Official Symbol: PROK1
• NCBI Official Synonym Symbols: PK1; PRK1; EGVEGF
• NCBI Protein Information: prokineticin-1
• UniProt Protein Name: Prokineticin-1
• Protein Family: Prokineticin
• UniProt Gene Name: PROK1
• UniProt Synonym Gene Names: EG-VEGF
• UniProt Entry Name: PROK1_HUMAN

NCBI Description

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

Uniprot Description

PROK1: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Belongs to the AVIT (prokineticin) family.

Protein type: Secreted; Secreted, signal peptide; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: extracellular region

Molecular Function: G-protein-coupled receptor binding; growth factor activity

Biological Process: activation of MAPK activity; angiogenesis; circadian rhythm; positive regulation of cell division; positive regulation of cell proliferation; regulation of angiogenesis