Rabbit Kv1.2Potassium Channel Polyclonal Antibody | anti-KCNA2 antibody

Kv1.2Potassium Channel

Cat. Num. AAA395806

• Gene Names: KCNA2; HK4; MK2; HBK5; NGK1; RBK2; HUKIV; KV1.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Ammonium Sulfate Precipitation
• Synonyms: Kv1.2Potassium Channel; Polyclonal Antibody; Voltage-Gated Potassium Channel; Kv1.2 isoform; anti-KCNA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Ammonium Sulfate Precipitation
• Form/Format: Provided as solution in phosphate buffered saline with 0.08% sodium azide
• Sequence Length: 356

• Applicable Applications for anti-KCNA2 antibody: Western Blot (WB)
• Immunogen: Synthetic peptide derived from the rat Kv1.2 potassium channel conjugated to KLH
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Related Product Information for anti-KCNA2 antibody

The Kv1.2 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaker potassium channel subfamily which includes Kv1.1, Kv1.3, Kv1.4 and Kv1.5. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In non?excitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.

Product Categories/Family for anti-KCNA2 antibody

Polyclonal Antibody; Ion Channels

NCBI and Uniprot Product Information

• NCBI GI #: 324022755
• NCBI GeneID: 3737
• NCBI Accession #: NP_001191198.1
• NCBI GenBank Nucleotide #: NM_001204269.1
• UniProt Accession #: P16389; Q86XG6
• Molecular Weight: 56,717 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 2 isoform b
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, member 2
• NCBI Official Symbol: KCNA2
• NCBI Official Synonym Symbols: HK4; MK2; HBK5; NGK1; RBK2; HUKIV; KV1.2
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 2; voltage-gated K(+) channel HuKIV; voltage-gated potassium channel HBK5; voltage-gated potassium channel protein Kv1.2; voltage-gated potassium channel subunit Kv1.2
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 2
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNA2
• UniProt Entry Name: KCNA2_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Post-translational modification: Phosphorylated on tyrosine residues by activated PTK2B/PYK2; this regulates ion channel activity

By similarity.

Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. [View classification]