Rabbit Kv1.5 Potassium Channel Polyclonal Antibody | anti-Kcna5 antibody

Kv1.5 Potassium Channel

Cat. Num. AAA395510

• Gene Names: Kcna5; Kv1; Kv1.5
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Ammonium Sulfate Precipitation
• Synonyms: Kv1.5 Potassium Channel; Polyclonal Antibody; Voltage-Gated Potassium Channel; Kv1.5 isoform; anti-Kcna5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Ammonium Sulfate Precipitation
• Form/Format: Provided as solution in phosphate buffered saline with 0.08% sodium azide
• Sequence Length: 602

• Applicable Applications for anti-Kcna5 antibody: Western Blot (WB)
• Immunogen: Synthetic peptide derived from the rat Kv1.5 potassium channel conjugated to KLH
• Positive Control: Rat brain lysate
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Western Blot/Blotting

(Western blot analysis)

Related Product Information for anti-Kcna5 antibody

The Kv1.5 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaker potassium channel subfamily which includes Kv1.1, Kv1.2, Kv1.3 and Kv1.4. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In non?excitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.

Product Categories/Family for anti-Kcna5 antibody

Polyclonal Antibody; Ion Channels

NCBI and Uniprot Product Information

• NCBI GI #: 6981118
• NCBI GeneID: 25470
• NCBI Accession #: NP_037104.1
• NCBI GenBank Nucleotide #: NM_012972.1
• UniProt Accession #: P19024; Q6LEB7
• Molecular Weight: 66,553 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily A member 5
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, member 5
• NCBI Official Symbol: Kcna5
• NCBI Official Synonym Symbols: Kv1; Kv1.5
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 5; RK4; RCK7; Potassium (K+) channel protein alpha 5; voltage-gated potassium channel subunit Kv1.5; potassium voltage gated channel, shaker related subfamily, member 5
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 5
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: Kcna5
• UniProt Entry Name: KCNA5_RAT

NCBI Description

voltage gated potassium channel; functions as a delayed rectifier-like K+ channel [RGD, Feb 2006]

Uniprot Description

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. Ref.5

Subunit structure: Heterotetramer of potassium channel proteins

By similarity. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3. Interacts with UBE2I

By similarity. Ref.4 Ref.5

Subcellular location: Membrane; Multi-pass membrane protein.

Tissue specificity: Expressed equally in atrium, ventricle, aorta and skeletal muscle. Weaker expression in brain. Ref.2

Induction: Expression regulated by cAMP in a tissue-specific manner. In primary cardiac cells, levels increase by 6-fold, and in GH3 cells, levels decrease 5-6-fold.

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. [View classification]