Western Blot (WB)
(WB Suggested Anti-KRT74 AntibodyTitration: 1.0 ug/mlPositive Control: 721_B Whole Cell)
Rabbit anti-Human KRT74 Polyclonal Antibody | anti-KRT74 antibody
KRT74 Antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-KRT74 AntibodyTitration: 1.0 ug/mlPositive Control: 721_B Whole Cell)
Western Blot (WB)
(WB Suggested Anti-KRT74 AntibodyTitration: 1.0 ug/mlPositive Control: 721_B Whole Cell)
Target Description: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.
NCBI and Uniprot Product Information
NCBI Description
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]
Uniprot Description
KRT74: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Defects in KRT74 are a cause of woolly hair autosomal dominant (ADWH). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Defects in KRT74 are the cause of hypotrichosis type 3 (HYPT3). A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Belongs to the intermediate filament family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytoplasm; keratin filament
Molecular Function: structural molecule activity
Biological Process: intermediate filament cytoskeleton organization and biogenesis
Disease: Ectodermal Dysplasia 7, Hair/nail Type; Woolly Hair, Autosomal Dominant; Hypotrichosis 3
Research Articles on KRT74
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Product Notes
The KRT74 krt74 (Catalog #AAA3217167) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KRT74 Antibody - C-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KRT74 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the KRT74 krt74 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: HPSSAGVDLG ASAVAGSSGS TQSGQTKTTE ARGGDLKDTQ GKSTPASIPA. It is sometimes possible for the material contained within the vial of "KRT74, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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