Rabbit anti-Human KPNA7 Polyclonal Antibody | anti-KPNA7 antibody

KPNA7 Antibody

Cat. Num. AAA150983

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: KPNA7 Antibody is affinity chromatography purified via peptide column.
• Synonyms: KPNA7; Polyclonal Antibody; KPNA7 Antibody; Importin subunit alpha-8; Karyopherin subunit alpha-7; karyopherin alpha 7 (importin alpha 8); anti-KPNA7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KPNA7 antibody is human specific. KPNA7 antibody is predicted to not cross-react with other Importin alpha family members.
• Purity/Purification: KPNA7 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 516

• Applicable Applications for anti-KPNA7 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: KPNA7 antibody can be used for detection of KPNA7 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.
• Conjugate: Unconjugated
• Immunogen: KPNA7 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA7.
• Buffer: KPNA7 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: KPNA7 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of KPNA7 in human spleen with KPNA7 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of KPNA7 in human placenta tissue with KPNA7 antibody at 5 μg/mL.)

Related Product Information for anti-KPNA7 antibody

KPNA7 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 224589129
• NCBI GeneID: 402569
• NCBI Accession #: NP_001139187
• NCBI GenBank Nucleotide #: NM_001145715.1
• UniProt Accession #: A9QM74; A4D277
• Molecular Weight: 56,938 Da
• NCBI Official Full Name: importin subunit alpha-8
• NCBI Official Synonym Full Names: karyopherin alpha 7 (importin alpha 8)
• NCBI Official Symbol: KPNA7
• NCBI Protein Information: importin subunit alpha-8; karyopherin 7; karyopherin subunit alpha-7
• UniProt Protein Name: Importin subunit alpha-8
• UniProt Gene Name: KPNA7
• UniProt Entry Name: IMA8_HUMAN

Uniprot Description

KPNA7: Functions in nuclear protein import. Belongs to the importin alpha family.

Protein type: Nuclear import

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein transporter activity

Biological Process: protein import into nucleus; cytokine and chemokine mediated signaling pathway