Rabbit KOR-1 Polyclonal Antibody | anti-KOR-1 antibody

KOR-1 (Phospho-S369) Polyclonal Antibody

Cat. Num. AAA3005073

• Gene Names: OPRK1; KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KOR-1; Polyclonal Antibody; KOR-1 (Phospho-S369) Polyclonal Antibody; Kappa-type opioid receptor; K-OR-1; OPRK1; OPRK; anti-KOR-1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KOR-1 (phospho-S369) polyclonal antibody detects endogenous levels of KOR-1 protein when phosphorylated at Ser369.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 380

• Applicable Applications for anti-KOR-1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic phosphopeptide derived from human KOR-1 around the phosphorylation site of Ser369.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of p-KOR-1 (S369) pAb at 1:500 dilutionLane1:U-87MG whole cell lysate (40ug) Lane2:PC3 whole cell lysate (40ug) Lane3:HepG2 whole cell lysate (40ug) Lane4:The Brain tissue lysate of Mouse (40ug) Lane5:The Brain tissue lysate of Rat (40ug))

Related Product Information for anti-KOR-1 antibody

Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins. The three opioid receptor types are highly homologous and belong to the superfamily of G-protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.

NCBI and Uniprot Product Information

• NCBI GI #: 39725940
• NCBI GeneID: 4986
• NCBI Accession #: NP_000903.2
• NCBI GenBank Nucleotide #: NP_000903.2
• UniProt Accession #: P41145
• Molecular Weight: ~ 42kDa
• NCBI Official Full Name: kappa-type opioid receptor isoform 1
• NCBI Official Synonym Full Names: opioid receptor kappa 1
• NCBI Official Symbol: OPRK1
• NCBI Official Synonym Symbols: KOP; KOR; KOR1; OPRK; KOR-1; K-OR-1
• NCBI Protein Information: kappa-type opioid receptor
• UniProt Protein Name: Kappa-type opioid receptor
• UniProt Gene Name: OPRK1
• UniProt Synonym Gene Names: OPRK; K-OR-1; KOR-1
• UniProt Entry Name: OPRK_HUMAN

NCBI Description

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Uniprot Description

KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: neuron projection; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; behavior; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; locomotory behavior; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of saliva secretion; sensory perception of pain; defense response to virus