Western Blot (WB)
(KLKB1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KLKB1 antibody detected the KLKB1 protein (arrow).)
Rabbit anti-Human KLKB1 Polyclonal Antibody | anti-KLKB1 antibody
KLKB1 Antibody (C-term)
Western Blot (WB)
(KLKB1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KLKB1 antibody detected the KLKB1 protein (arrow).)
Western Blot (WB)
(KLKB1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KLKB1 antibody detected the KLKB1 protein (arrow).)
in the surface-dependent activation of blood coagulation,
fibrinolysis, kinin generation and inflammation. It is synthesized
in the liver and secreted into the blood as a single polypeptide
chain. Plasma prekallikrein is converted to plasma kallikrein by
factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma
kallikrein therefore is composed of a heavy chain and a light chain
held together by a disulphide bond. The heavy chain originates
from the amino-terminal end of the zymogen and contains 4 tandem
repeats of 90 or 91 amino acids. Each repeat harbors a novel
structure called the apple domain. The heavy chain is required for
the surface-dependent pro-coagulant activity of plasma kallikrein.
The light chain contains the active site or catalytic domain of the
enzyme and is homologous to the trypsin family of serine proteases.
Plasma prekallikrein deficiency causes a prolonged activated
partial thromboplastin time in patients.
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Eeckhoudt, S.L., et al. Thromb. Haemost. 103(4):866-867(2010)
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :
NCBI and Uniprot Product Information
NCBI Description
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
Uniprot Description
KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Protein type: Protease; Secreted, signal peptide; EC 3.4.21.34; Secreted
Chromosomal Location of Human Ortholog: 4q35
Cellular Component: extracellular space; plasma membrane; extracellular region
Molecular Function: protein binding; serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; fibrinolysis; extracellular matrix organization and biogenesis; positive regulation of fibrinolysis; zymogen activation; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; plasminogen activation; Factor XII activation
Disease: Prekallikrein Deficiency
Research Articles on KLKB1
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Product Notes
The KLKB1 klkb1 (Catalog #AAA9214960) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 508-537. The KLKB1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KLKB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the KLKB1 klkb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KLKB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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