Goat KLK6 / Kallikrein 6 Polyclonal Antibody | anti-KLK6 antibody

Goat Polyclonal to Human KLK6 / Kallikrein 6

Cat. Num. AAA248421

• Gene Names: KLK6; hK6; Bssp; Klk7; SP59; PRSS9; PRSS18
• Reactivity: Human, Monkey
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: KLK6 / Kallikrein 6; Polyclonal Antibody; Goat Polyclonal to Human KLK6 / Kallikrein 6; Anti-KLK6 / Kallikrein 6 Antibody (aa145-156) IHC-plus; KLK6; Bssp; HK6; Kallikrein-related peptidase 6; Kallikrein 6 (neurosin; zyme); Neurosin; Protease; serine; 18; Protease M; PRSS9; Serine protease 9; Zyme; Serine protease 18; Kallikrein 6; Kallikrein-6; PRSS18; SP59; Human KLK6; anti-KLK6 antibody

• Host: Goat
• Reactivity: Human, Monkey
• Clonality: Polyclonal
• Specificity: Human KLK6 / Kallikrein 6. This antibody is expected to recognize both reported isoforms (NP_002765.1; NP_001012983.1). Reported variants represent identical protein: NP_002765.1, NP_001012982.1.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 244

• Applicable Applications for anti-KLK6 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:128000), IHC-P (5 ug/ml); Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Preliminary experiments gave an approx 50kD band in Human Ovary lysates after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the litera...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-KTADGDFPDTIQ from an internal region of human KLK6 / Kallikrein 6 (NP_002765.1; NP_001012983.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey (100%); Elephant (92%); Ferret, Panda, Horse (83%); Mouse (75%); Rat (67%).
• Immunogen Type: Synthetic peptide
• Immunogen: KLK6 / Kallikrein 6 antibody was raised against synthetic peptide C-KTADGDFPDTIQ from an internal region of human KLK6 / Kallikrein 6 (NP_002765.1; NP_001012983.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey (100%); Elephant (92%); Ferret, Panda, Horse (83%); Mouse (75%); Rat (67%).
• Antigen Modification: aa145-156
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-KLK6 / Kallikrein 6 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-KLK6 / Kallikrein 6 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-KLK6 antibody

Human kallikrein 6 (hK6) is a trypsin-like serine protease, member of the human kallikrein gene family. Studies suggested a potential involvement of hK6 in the development and progression of Alzheimer's disease and ovarian cancer.

Product Categories/Family for anti-KLK6 antibody

Family: Protease; Subfamily: Serine S1

NCBI and Uniprot Product Information

• NCBI GI #: 4506155
• NCBI GeneID: 5653
• NCBI Accession #: NP_002765.1
• NCBI GenBank Nucleotide #: NM_002774.3
• UniProt Accession #: Q92876; Q6H301; A6NJA1; A8MW09
• Molecular Weight: 4,333 Da
• NCBI Official Full Name: kallikrein-6 isoform A preproprotein
• NCBI Official Synonym Full Names: kallikrein-related peptidase 6
• NCBI Official Symbol: KLK6
• NCBI Official Synonym Symbols: hK6; Bssp; Klk7; SP59; PRSS9; PRSS18
• NCBI Protein Information: kallikrein-6; zyme; neurosin; protease M; serine protease 9; serine protease 18
• UniProt Protein Name: Kallikrein-6
• Protein Family: Kallikrein
• UniProt Gene Name: KLK6
• UniProt Synonym Gene Names: PRSS18; PRSS9
• UniProt Entry Name: KLK6_HUMAN

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Protease; Nucleolus; Secreted, signal peptide; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: microtubule cytoskeleton; nucleoplasm; extracellular space; nuclear membrane; intercellular bridge; mitochondrion; endoplasmic reticulum; cytoplasm; nucleolus; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: myelination; protein autoprocessing; collagen catabolic process; central nervous system development; amyloid precursor protein metabolic process; tissue regeneration; positive regulation of G-protein coupled receptor protein signaling pathway; regulation of cell differentiation; response to wounding; hormone metabolic process; protein processing; proteolysis