Rabbit anti-Human KLK12 Polyclonal Antibody | anti-KLK12 antibody

KLK12, ID (KLK12, KLKL5, Kallikrein-12, Kallikrein-like protein 5) (FITC)

Cat. Num. AAA6314274

• Gene Names: KLK12; KLKL5; KLK-L5
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KLK12; Polyclonal Antibody; ID (KLK12; KLKL5; Kallikrein-12; Kallikrein-like protein 5) (FITC); Kallikrein-like protein 5; anti-KLK12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-KLK12 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLK12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-113 amino acids from the Central region of human KLK12.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KLK12 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the KLK12 antibody detected the KLK12 protein (arrow).)

Related Product Information for anti-KLK12 antibody

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq].

Product Categories/Family for anti-KLK12 antibody

Antibodies; Kallikrein

References

Klein, R.J., et al. Cancer Prev Res (Phila) 3(5):611-619(2010). Memari, N., et al. Biol. Chem. 388(4):427-435(2007). Lundwall, A., et al. Biol. Chem. 387(6):637-641(2006). Shinmura, K., et al. Hum. Mutat. 24(3):273-274(2004). Grimwood, J., et al. Nature 428(6982):529-535(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 9665236
• NCBI GeneID: 43849
• NCBI Accession #: NP_062544.1; NP_665901.1
• NCBI GenBank Nucleotide #: NM_019598.2
• UniProt Accession #: Q9UKR0; Q9UKR1; Q9UKR2
• Molecular Weight: 11,984 Da
• NCBI Official Full Name: kallikrein-12 isoform 1
• NCBI Official Synonym Full Names: kallikrein related peptidase 12
• NCBI Official Symbol: KLK12
• NCBI Official Synonym Symbols: KLKL5; KLK-L5
• NCBI Protein Information: kallikrein-12
• UniProt Protein Name: Kallikrein-12
• Protein Family: Kallikrein
• UniProt Gene Name: KLK12
• UniProt Synonym Gene Names: KLKL5; KLK-L5
• UniProt Entry Name: KLK12_HUMAN

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

KLK12: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space

Molecular Function: peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis