Western Blot (WB)
(Gel: 10%SDS-PAGE Lysate: 40 μ g Lane: Jurkat cells Primary antibody: 1/250 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes)
Rabbit KL Polyclonal Antibody | anti-KL antibody
KL Antibody
Western Blot (WB)
(Gel: 10%SDS-PAGE Lysate: 40 μ g Lane: Jurkat cells Primary antibody: 1/250 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes)
Western Blot (WB)
(Gel: 10%SDS-PAGE Lysate: 40 μ g Lane: Jurkat cells Primary antibody: 1/250 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes)
NCBI and Uniprot Product Information
Uniprot Description
Klotho: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.2.1.31; Hydrolase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: extracellular region; integral to plasma membrane; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; beta-glucosidase activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: aging; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; phosphoinositide-mediated signaling; positive regulation of bone mineralization; regulation of phosphoinositide 3-kinase cascade
Disease: Tumoral Calcinosis, Hyperphosphatemic, Familial
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Product Notes
The KL kl (Catalog #AAA9416256) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KL Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:200-1:1000. Researchers should empirically determine the suitability of the KL kl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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