Testing Data
Rabbit anti-Rat Kir2.1 Polyclonal Antibody | anti-Kir2.1 antibody
Anti-Kir2.1 Antibody
Gene Names
KCNJ2; KIR2.1
Reactivity
Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity Purified On Immobilized Antigen.
Synonyms
Kir2.1; Polyclonal Antibody; Anti-Kir2.1 Antibody; anti-Kir2.1 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Specificity
Rabbit, bovine, pig, guinea pig-identical; rat, mouse-17/19 residues identical; chicken-15/19 residues identical; pigeon-14/18 residues identical.
Purity/Purification
Affinity Purified On Immobilized Antigen.
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Sequence Length
427
Applicable Applications for anti-Kir2.1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: Rat brain and rat heart membranes (1:200).
IHC: Rat heart sections.
IHC: Rat heart sections.
Immunogen
Peptide (C)NGVPESTSTDTPPDIDLHN, corresponding to amino acid residues 392-410 of human Kir2.1 (Accession P48049).
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Related Product Information for anti-Kir2.1 antibody
IRK1, Kcnj2 Kir2.1 is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.1 The family's topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N-and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heterotetramers. Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis. Kir2.1 is a member of the Kir2.x subfamily that includes four members (Kir2.1-Kir2.4) that are characterized by strong inward rectification and high constitutive activity. Kir2.1 is expressed in a variety of tissues including heart, brain, vascular smooth muscle cells and skeletal muscles. In heart, Kir2.1 is a molecular component of the IK1 current that is responsible for setting the resting membrane potential, preventing membrane hyperpolarization due to Na+ pump activity, influencing propagation velocity, altering the electrical space constant, and promoting late phase repolarization.2 In fact, mutations in Kir2.1 channels have been linked to a form of long QT syndrome (LQT7) known as Andersen's syndrome that is characterized by cardiac arrhythmias, periodic paralysis, and dysmorphic features.3
NCBI and Uniprot Product Information
Similar Products
Product Notes
The Kir2.1 (Catalog #AAA4159230) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Kir2.1 Antibody reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Kir2.1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: Rat brain and rat heart membranes (1:200). IHC: Rat heart sections. Researchers should empirically determine the suitability of the Kir2.1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kir2.1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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