Western Blot (WB)
(Western blot analysis of KCNJ2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). KCNJ2 (arrow) was detected using the purified Pab.)
Rabbit anti-Human, Mouse Kir2.1 Polyclonal Antibody | anti-Kir2.1 antibody
Kir2.1, CT (Cardiac Inward Rectifier Potassium Channel, HHBIRK1, HHIRK1, Inward Rectifier Potassium Channel 2, Inward Rectifier K(+) Channel Kir2.1, IRK1, IRK-1, hIRK1, LQT7, Potassium Channel Inwardly Rectifying Subfamily J Member 2, KCNJ2, SQT3) (Biotin
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of KCNJ2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). KCNJ2 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of KCNJ2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). KCNJ2 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of KCNJ2 Antibody (C-term) in mouse lung tissue lysates (35ug/lane). KCNJ2 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of KCNJ2 Antibody (C-term) in mouse lung tissue lysates (35ug/lane). KCNJ2 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human lung carcinoma reacted with KCNJ2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human lung carcinoma reacted with KCNJ2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(KCNJ2 Antibody (C-term) flow cytometry analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(KCNJ2 Antibody (C-term) flow cytometry analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
NCBI and Uniprot Product Information
NCBI Description
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]
Uniprot Description
KCNJ2: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7); also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features. Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves. Defects in KCNJ2 are the cause of familial atrial fibrillation type 9 (ATFB9). ATFB9 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q24.3
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; smooth endoplasmic reticulum; rough endoplasmic reticulum; cell soma; integral to plasma membrane; T-tubule; plasma membrane; dendritic spine; intrinsic to membrane
Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; inward rectifier potassium channel activity
Biological Process: synaptic transmission; regulation of skeletal muscle contraction via membrane action potential; potassium ion import; regulation of resting membrane potential; cellular potassium ion homeostasis; potassium ion transport; protein homotetramerization; magnesium ion transport
Disease: Atrial Fibrillation, Familial, 9; Andersen Cardiodysrhythmic Periodic Paralysis; Short Qt Syndrome 3
Research Articles on Kir2.1
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Product Notes
The Kir2.1 kcnj2 (Catalog #AAA6484406) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Kir2.1, CT (Cardiac Inward Rectifier Potassium Channel, HHBIRK1, HHIRK1, Inward Rectifier Potassium Channel 2, Inward Rectifier K(+) Channel Kir2.1, IRK1, IRK-1, hIRK1, LQT7, Potassium Channel Inwardly Rectifying Subfamily J Member 2, KCNJ2, SQT3) (Biotin reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Kir2.1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-1:500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the Kir2.1 kcnj2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kir2.1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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