Rabbit KHSRP Polyclonal Antibody | anti-KHSRP antibody

KHSRP Rabbit Polyclonal

Cat. Num. AAA7600758

• Gene Names: KHSRP; FBP2; KSRP; FUBP2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: KHSRP; Polyclonal Antibody; KHSRP Rabbit Polyclonal; anti-KHSRP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 710

• Applicable Applications for anti-KHSRP antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: KH-type splicing regulatory protein
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis using MBS7600758 (KHSRP antibody) at dilution of 1:50)

Immunofluorescence (IF)

(Immunofluorescent analysis of HeLa cells using MBS7600758 (KHSRP antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG (H+L))

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7600758 (KHSRP antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 54648253
• NCBI GeneID: 8570
• Molecular Weight: 73,115 Da
• NCBI Official Full Name: KHSRP protein
• NCBI Official Synonym Full Names: KH-type splicing regulatory protein
• NCBI Official Symbol: KHSRP
• NCBI Official Synonym Symbols: FBP2; KSRP; FUBP2
• NCBI Protein Information: far upstream element-binding protein 2
• UniProt Protein Name: Far upstream element-binding protein 2
• Protein Family: Far upstream element-binding protein
• UniProt Gene Name: KHSRP
• UniProt Synonym Gene Names: FUBP2; FUSE-binding protein 2; KSRP
• UniProt Entry Name: FUBP2_HUMAN

NCBI Description

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Uniprot Description

KHSRP: an RNA binding and processing protein that binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' untranslated regions, possibly by recruiting degradation machinery to ARE-containing mRNAs. Interacts with APC which is part of the apolipoprotein B mRNA editing enzyme complex. The interaction is not required for activity of the catalytic component, APOBEC1, but may confer stability on the complex.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cell soma; cytosol; dendrite; membrane; nucleoplasm; stress granule

Molecular Function: DNA binding; mRNA 3'-UTR binding

Biological Process: mRNA catabolic process; mRNA processing; mRNA transport; regulation of mRNA stability; regulation of transcription, DNA-dependent; RNA splicing; RNA splicing, via transesterification reactions; transcription, DNA-dependent