Rabbit ADORA1 / Adenosine A1 Receptor Polyclonal Antibody | anti-ADORA1 antibody

Rabbit Polyclonal to Human ADORA1 / Adenosine A1 Receptor

Cat. Num. AAA248179

• Gene Names: ADORA1; RDC7
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: ADORA1 / Adenosine A1 Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human ADORA1 / Adenosine A1 Receptor; Anti-ADORA1 / Adenosine A1 Receptor Antibody (Asp326) IHC-plus; A1 adenosine receptor; A1ar; Adenosine A1 receptor; Adenosine receptor A1; ADO-A1 receptor; RDC7; Human ADORA1; Adenosine A1 Receptor; anti-ADORA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human Adenosine A1 Receptor / ADORA1
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.2, 0.05% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 326

• Applicable Applications for anti-ADORA1 antibody: Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)
• Application Notes: IF (1:50 - 1:200), IHC-P (5 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide around Asp326 of human Adenosine A1 Receptor / ADORA1
• Immunogen Type: Synthetic peptide
• Immunogen: ADORA1 / Adenosine A1 Receptor antibody was raised against synthetic peptide around Asp326 of human Adenosine A1 Receptor / ADORA1
• Antigen Modification: Asp326
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-ADORA1 / Adenosine A1 Receptor antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-ADORA1 / Adenosine A1 Receptor antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(Western blot of Adenosine A1-R (D326) pAb in extracts from MCF-7 cells.)

Related Product Information for anti-ADORA1 antibody

The A1 Adenosine Receptor is involved in smooth muscle contraction, control of heart rate, sedation, and lipolysis.

Product Categories/Family for anti-ADORA1 antibody

Family: GPCR; Subfamily: Adenosine

NCBI and Uniprot Product Information

• NCBI GI #: 4501947
• NCBI GeneID: 134
• NCBI Accession #: NP_000665.1
• NCBI GenBank Nucleotide #: NM_000674.2
• UniProt Accession #: P30542; Q6FHK3; Q8TAM8; A6NFY5; A6NGP4; A8K1L3; B3KXQ4; D2CGD0
• Molecular Weight: 13,348 Da
• NCBI Official Full Name: adenosine receptor A1
• NCBI Official Synonym Full Names: adenosine A1 receptor
• NCBI Official Symbol: ADORA1
• NCBI Official Synonym Symbols: RDC7
• NCBI Protein Information: adenosine receptor A1; adenosine A1 receptor variant 1
• UniProt Protein Name: Adenosine receptor A1
• Protein Family: Adenosine receptor
• UniProt Gene Name: ADORA1
• UniProt Entry Name: AA1R_HUMAN

NCBI Description

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; Apoptosis; GPCR, family 1; Membrane protein, multi-pass; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: basolateral plasma membrane; endoplasmic reticulum; integral to plasma membrane; postsynaptic density; dendritic spine; terminal button; axolemma; presynaptic membrane; asymmetric synapse; postsynaptic membrane; cell soma; presynaptic active zone; plasma membrane

Molecular Function: protein binding; G-protein-coupled receptor binding; protein heterodimerization activity; G-protein beta/gamma-subunit binding; purine nucleoside binding; adenosine receptor activity, G-protein coupled; phospholipase C activity; heterotrimeric G-protein binding

Biological Process: negative regulation of circadian sleep/wake cycle, non-REM sleep; relaxation of vascular smooth muscle; negative regulation of glutamate secretion; activation of MAPKK activity; negative regulation of hormone secretion; positive regulation of potassium ion transport; regulation of synaptic plasticity; positive regulation of peptide secretion; neurological control of breathing; thermoregulation; signal transduction; positive regulation of protein amino acid dephosphorylation; negative regulation of cell proliferation; regulation of glomerular filtration; negative regulation of vasodilation; cell-cell signaling; positive regulation of epidermal growth factor receptor activity; negative regulation of lipid catabolic process; positive regulation of nucleoside transport; negative regulation of blood pressure; inflammatory response; protein targeting to membrane; detection of temperature stimulus involved in sensory perception of pain; negative regulation of synaptic transmission, GABAergic; adenosine receptor signaling pathway; nervous system development; negative regulation of neurotrophin production; negative regulation of acute inflammatory response; negative regulation of synaptic transmission, glutamatergic; negative regulation of leukocyte migration; phagocytosis; response to hypoxia; regulation of sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of excitatory postsynaptic membrane potential; cognition; positive regulation of blood pressure; lipid catabolic process; negative regulation of apoptosis