Western Blot (WB)
(Western blot analysis of extracts from 3T3, using KDM4C / GASC1 / JMJD2C Antibody. The lane on the left was treated with blocking peptide.Observed bands: 200 kDa.)
Rabbit KDM4C/GASC1/JMJD2C Polyclonal Antibody | anti-KDM4C antibody
KDM4C/GASC1/JMJD2C Antibody
Gene Names
KDM4C; GASC1; JHDM3C; JMJD2C; TDRD14C
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
KDM4C/GASC1/JMJD2C; Polyclonal Antibody; KDM4C/GASC1/JMJD2C Antibody; bA146B14.1; GASC 1 protein; GASC-1 protein; GASC1; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain containing histone demethylation protein 3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; Jumonji domain containing 2C; Jumonji domain containing protein 2C; Jumonji domain-containing protein 2C; Kdm4c; KDM4C_HUMAN; Lysine (K) specific demethylase 4C; Lysine demethylase 4C; Lysine-specific demethylase 4C; TDRD14C; Tudor domain containing 14C; anti-KDM4C antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
KDM4C / GASC1 / JMJD2C Antibody detects endogenous levels of total KDM4C / GASC1 / JMJD2C.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1mg/ml (varies by lot)
Sequence Length
1056
Applicable Applications for anti-KDM4C antibody
ELISA (EIA)
Application Notes
WB: 1:500-1:2000
ELISA(peptide): 1:20,000-1:40,000
ELISA(peptide): 1:20,000-1:40,000
Immunogen
A synthesized peptide derived from human KDM4C / GASC1 / JMJD2C, corresponding to a region within the internal amino acids.
Fragment
Fab fragment
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from 3T3, using KDM4C / GASC1 / JMJD2C Antibody. The lane on the left was treated with blocking peptide.Observed bands: 200 kDa.)
Western Blot (WB)
(Western blot analysis of extracts from 3T3, using KDM4C / GASC1 / JMJD2C Antibody. The lane on the left was treated with blocking peptide.Observed bands: 200 kDa.)
Related Product Information for anti-KDM4C antibody
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Subcellular Location: Nucleus.
Tissue Specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Similarity: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity).Belongs to the JHDM3 histone demethylase family.
Subcellular Location: Nucleus.
Tissue Specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Similarity: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity).Belongs to the JHDM3 histone demethylase family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed Molecular Weight: (Observed)119kD, 200kD.
Predicted Molecular Weight: (Calculated)120kDa.
Predicted Molecular Weight: (Calculated)120kDa.
NCBI Official Full Name
lysine-specific demethylase 4C isoform 1
NCBI Official Synonym Full Names
lysine demethylase 4C
NCBI Official Symbol
KDM4C
NCBI Official Synonym Symbols
GASC1; JHDM3C; JMJD2C; TDRD14C
NCBI Protein Information
lysine-specific demethylase 4C
UniProt Protein Name
Lysine-specific demethylase 4C
Protein Family
UniProt Gene Name
KDM4C
UniProt Synonym Gene Names
GASC1; JHDM3C; JMJD2C; KIAA0780
UniProt Entry Name
KDM4C_HUMAN
NCBI Description
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Research Articles on KDM4C
Similar Products
Product Notes
The KDM4C kdm4c (Catalog #AAA9612326) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KDM4C/GASC1/JMJD2C Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KDM4C/GASC1/JMJD2C can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). WB: 1:500-1:2000 ELISA(peptide): 1:20,000-1:40,000. Researchers should empirically determine the suitability of the KDM4C kdm4c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KDM4C/GASC1/JMJD2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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