Western Blot (WB)
(KCNV2 Antibody (C-term) western blot analysis in 293,K562,HepG2,Jurkat,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the KCNV2 antibody detected the KCNV2 protein (arrow).)
Rabbit KCNV2 Polyclonal Antibody | anti-KCNV2 antibody
KCNV2 Antibody (C-term)
Western Blot (WB)
(KCNV2 Antibody (C-term) western blot analysis in 293,K562,HepG2,Jurkat,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the KCNV2 antibody detected the KCNV2 protein (arrow).)
Western Blot (WB)
(KCNV2 Antibody (C-term) western blot analysis in 293,K562,HepG2,Jurkat,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the KCNV2 antibody detected the KCNV2 protein (arrow).)
Immunohistochemistry (IHC)
(KCNV2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNV2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(KCNV2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNV2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
complex class of voltage-gated ion channels from both functional
and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion,
neuronal excitability, epithelial electrolyte transport, smooth
muscle contraction, and cell volume. This gene encodes a member of
the potassium voltage-gated channel subfamily V. This member is
identified as a 'silent subunit', and it does not form
homomultimers, but forms heteromultimers with several other
subfamily members. Through obligatory heteromerization, it exerts a
function-altering effect on other potassium channel subunits. This
protein is strongly expressed in pancreas and has a weaker
expression in several other tissues.
Ben Salah, S., et al. Am. J. Ophthalmol. 145(6):1099-1106(2008)
Wissinger, B., et al. Invest. Ophthalmol. Vis. Sci. 49(2):751-757(2008)
Thiagalingam, S., et al. Ophthalmic Genet. 28(3):135-142(2007)
Balijepalli, R.C., et al. Channels (Austin) 1(4):263-272(2007)
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv8.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B); also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane
Molecular Function: delayed rectifier potassium channel activity
Biological Process: synaptic transmission; protein homooligomerization
Disease: Retinal Cone Dystrophy 3b
Research Articles on KCNV2
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Product Notes
The KCNV2 kcnv2 (Catalog #AAA9212281) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 478-507. The KCNV2 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's KCNV2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the KCNV2 kcnv2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNV2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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