Rabbit anti-Human KCNV2 Polyclonal Antibody | anti-KCNV2 antibody

KCNV2, CT (KCNV2, Potassium voltage-gated channel subfamily V member 2, Voltage-gated potassium channel subunit Kv8.2) (FITC)

Cat. Num. AAA6312789

• Gene Names: KCNV2; Kv8.2; RCD3B; KV11.1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNV2; Polyclonal Antibody; CT (KCNV2; Potassium voltage-gated channel subfamily V member 2; Voltage-gated potassium channel subunit Kv8.2) (FITC); Voltage-gated potassium channel subunit Kv8.2; anti-KCNV2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-KCNV2 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: KCNV2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-507 amino acids from the C-terminal region of human KCNV2.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNV2 Antibody (C-term) western blot analysis in 293,K562,HepG2,Jurkat,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the KCNV2 antibody detected the KCNV2 protein (arrow).)

Immunohistochemistry (IHC)

(KCNV2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNV2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-KCNV2 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues.

Product Categories/Family for anti-KCNV2 antibody

Antibodies; Ion Channel

References

Robson, A.G., et al. Retina (Philadelphia, Pa.) 30(1):51-62(2010). Ben Salah, S., et al. Am. J. Ophthalmol. 145(6):1099-1106(2008). Wissinger, B., et al. Invest. Ophthalmol. Vis. Sci. 49(2):751-757(2008). Thiagalingam, S., et al. Ophthalmic Genet. 28(3):135-142(2007). Balijepalli, R.C., et al. Channels (Austin) 1(4):263-272(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 19424136
• NCBI GeneID: 169522
• NCBI Accession #: NP_598004.1
• NCBI GenBank Nucleotide #: NM_133497.3
• UniProt Accession #: Q8TDN2; Q5T6X0
• Molecular Weight: 62,459 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily V member 2
• NCBI Official Synonym Full Names: potassium channel, subfamily V, member 2
• NCBI Official Symbol: KCNV2
• NCBI Official Synonym Symbols: Kv8.2; RCD3B; KV11.1
• NCBI Protein Information: potassium voltage-gated channel subfamily V member 2; voltage-gated potassium channel subunit Kv8.2
• UniProt Protein Name: Potassium voltage-gated channel subfamily V member 2
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNV2
• UniProt Entry Name: KCNV2_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv8.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B); also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: voltage-gated potassium channel complex; plasma membrane; integral to membrane

Molecular Function: delayed rectifier potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization

Disease: Retinal Cone Dystrophy 3b