Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using KCNU1 Polyclonal Antibody at dilution of 1:25(×200))
Rabbit anti-Human KCNU1 Polyclonal Antibody | anti-KCNU1 antibody
KCNU1 Polyclonal Antibody
ELISA: 1:5000-1:10000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using KCNU1 Polyclonal Antibody at dilution of 1:25(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using KCNU1 Polyclonal Antibody at dilution of 1:25(×200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Description
KCNU1: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8p11.23
Cellular Component: plasma membrane; voltage-gated potassium channel complex
Molecular Function: large conductance calcium-activated potassium channel activity; potassium channel activity; voltage-gated potassium channel activity
Biological Process: sperm-egg recognition
Research Articles on KCNU1
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Product Notes
The KCNU1 kcnu1 (Catalog #AAA2561988) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KCNU1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KCNU1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:25-1:100 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the KCNU1 kcnu1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNU1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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