Rabbit anti-Human KCNK10 Polyclonal Antibody | anti-KCNK10 antibody

KCNK10, CT (KCNK10, TREK2, Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit) (APC)

Cat. Num. AAA6312622

• Gene Names: KCNK10; TREK2; TREK-2; K2p10.1; PPP1R97
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNK10; Polyclonal Antibody; CT (KCNK10; TREK2; Potassium channel subfamily K member 10; Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit) (APC); TREK-2 K(+) channel subunit; anti-KCNK10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-KCNK10 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 503-532 amino acids from the C-terminal region of human KCNK10.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(KCNK10 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KCNK10 antibody detected the KCNK10 protein (arrow).)

Related Product Information for anti-KCNK10 antibody

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq].

Product Categories/Family for anti-KCNK10 antibody

Antibodies; Ion Channel

References

Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008). Huang, D., et al. Med. Hypotheses 70(3):618-624(2008). Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005). Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002): Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 10863961
• NCBI GeneID: 54207
• NCBI Accession #: NP_066984.1; NP_612190.1
• NCBI GenBank Nucleotide #: NM_021161.4
• UniProt Accession #: P57789; Q6B014; Q8TDK7; Q8TDK8; Q9HB59; B2R8T4; B2RCT3; B5TJL4
• Molecular Weight: 60,335 Da
• NCBI Official Full Name: potassium channel subfamily K member 10 isoform 1
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 10
• NCBI Official Symbol: KCNK10
• NCBI Official Synonym Symbols: TREK2; TREK-2; K2p10.1; PPP1R97
• NCBI Protein Information: potassium channel subfamily K member 10
• UniProt Protein Name: Potassium channel subfamily K member 10
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: KCNK10
• UniProt Synonym Gene Names: TREK2

NCBI Description

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

Uniprot Description

TREK-2: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q31.3

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: potassium channel activity; potassium ion leak channel activity; voltage-gated ion channel activity

Biological Process: memory; signal transduction; stabilization of membrane potential; transport