Western Blot (WB)
(HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with (1ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.)
Goat KCNIP3 Polyclonal Antibody | anti-KCNIP3 antibody
Goat anti-KCNIP3 Antibody
Western Blot: In transfected HEK293 transiently expressing Human KCNIP3 a band of approx.30kDa was observed. No bands are observed in the non-transfected HEK293. The calculated molecular size is 29.2kDa according to NP_038462.1. Recommended concentration, 1-3ug/ml.
Western Blot (WB)
(HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with (1ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
(HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with (1ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.
Protein type: Calcium-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q21.1
Cellular Component: cytosol; dendrite; endoplasmic reticulum; Golgi apparatus; nerve terminal; nucleus; plasma membrane; voltage-gated potassium channel complex
Molecular Function: calcium ion binding; DNA binding; potassium channel activity; potassium channel regulator activity; protein binding; transcription corepressor activity; voltage-gated ion channel activity
Biological Process: apoptosis; intracellular protein transport; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; signal transduction; transcription, DNA-dependent
Research Articles on KCNIP3
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Product Notes
The KCNIP3 kcnip3 (Catalog #AAA423101) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-KCNIP3 Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's KCNIP3 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB-Trf). Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: In transfected HEK293 transiently expressing Human KCNIP3 a band of approx.30kDa was observed. No bands are observed in the non-transfected HEK293. The calculated molecular size is 29.2kDa according to NP_038462.1. Recommended concentration, 1-3ug/ml. Researchers should empirically determine the suitability of the KCNIP3 kcnip3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HTPLSKKEGI K. It is sometimes possible for the material contained within the vial of "KCNIP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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