Rabbit anti-Human, Mouse KCNG3 Polyclonal Antibody | anti-KCNG3 antibody

KCNG3, NT (KCNG3, Potassium voltage-gated channel subfamily G member 3, Voltage-gated potassium channel subunit Kv10.1, Voltage-gated potassium channel subunit Kv6.3) (Azide free) (HRP)

Cat. Num. AAA6312427

• Gene Names: KCNG3; KV6.3; KV10.1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNG3; Polyclonal Antibody; NT (KCNG3; Potassium voltage-gated channel subfamily G member 3; Voltage-gated potassium channel subunit Kv10.1; Voltage-gated potassium channel subunit Kv6.3) (Azide free) (HRP); Voltage-gated potassium channel subunit Kv6.3; anti-KCNG3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-KCNG3 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:50-100; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: KCNG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acid 15-45 from the N-terminal region of human KCNG3.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of KCNG3 Antibody (N-term) in mouse liver tissue lysates (35ug/lane). KCNG3 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(KCNG3 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNG3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-KCNG3 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule.

Product Categories/Family for anti-KCNG3 antibody

Antibodies; Ion Channel

References

Mederos Y Schnitzler, M., et al. J. Biol. Chem. 284(7):4695-4704(2009). Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005). Vega-Saenz de Miera, E.C. Brain Res. Mol. Brain Res. 123 (1-2), 91-103 (2004).

NCBI and Uniprot Product Information

• NCBI GI #: 19071574
• NCBI GeneID: 170850
• NCBI Accession #: NP_579875.1
• NCBI GenBank Nucleotide #: NM_133329.5
• UniProt Accession #: Q8TAE7; Q53SC1
• Molecular Weight: 49,593 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily G member 3 isoform 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel, subfamily G, member 3
• NCBI Official Symbol: KCNG3
• NCBI Official Synonym Symbols: KV6.3; KV10.1
• NCBI Protein Information: potassium voltage-gated channel subfamily G member 3; voltage-gated potassium channel 6.3; voltage-gated potassium channel Kv10.1; voltage-gated potassium channel subunit Kv6.3; voltage-gated potassium channel subunit Kv6.4; voltage-gated potassium channe
• UniProt Protein Name: Potassium voltage-gated channel subfamily G member 3
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNG3
• UniProt Entry Name: KCNG3_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

KCNG3: Potassium channel subunit. Modulates channel activity. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: voltage-gated potassium channel complex; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: protein binding; delayed rectifier potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization