Rabbit KCNB1 Polyclonal Antibody | anti-KCNB1 antibody

KCNB1 (Phospho-S805) Polyclonal Antibody

Cat. Num. AAA3007941

• Gene Names: KCNB1; DRK1; Kv2.1
• Reactivity: Human, Rat, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KCNB1; Polyclonal Antibody; KCNB1 (Phospho-S805) Polyclonal Antibody; Potassium voltage-gated channel subfamily B member 1; Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1; anti-KCNB1 antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Specificity: KCNB1 (phospho-S805) polyclonal antibody detects endogenous levels of KCNB1 protein only when phosphorylated at Ser805.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
• Sequence Length: 858

• Applicable Applications for anti-KCNB1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic phosphopeptide derived from human KCNB1 around the phosphorylation site of Serine805.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of KCNB1 (phospho-S805) polyclonal antibody at 1:500 dilutionLane1:CT26 whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:Panc1 whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:U-87MG whole cell lysate (40ug))

Related Product Information for anti-KCNB1 antibody

KCNB1, also named as DRK1, KV2.1, and h-DRK1, belongs to the potassium channel family and B (Shab) subfamily. KCNB1 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. The antibody is specific to KCNB1.

NCBI and Uniprot Product Information

• NCBI GI #: 4826784
• NCBI GeneID: 3745
• NCBI Accession #: NP_004966.1
• NCBI GenBank Nucleotide #: NP_004966.1
• UniProt Accession #: Q14721
• Molecular Weight: ~ 100kDa
• NCBI Official Full Name: potassium voltage-gated channel subfamily B member 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily B member 1
• NCBI Official Symbol: KCNB1
• NCBI Official Synonym Symbols: DRK1; Kv2.1
• NCBI Protein Information: potassium voltage-gated channel subfamily B member 1
• UniProt Protein Name: Potassium voltage-gated channel subfamily B member 1
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNB1
• UniProt Synonym Gene Names: DRK1; h-DRK1
• UniProt Entry Name: KCNB1_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.

Protein type: Membrane protein, integral; Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; integral to membrane; plasma membrane

Molecular Function: protein binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein N-terminus binding

Biological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Epileptic Encephalopathy, Early Infantile, 26