Rabbit KCNB1 Polyclonal Antibody | anti-KCNB1 antibody

KCNB1 Polyclonal Antibody

Cat. Num. AAA2517006

• Gene Names: KCNB1; DRK1; KV2.1; EIEE26; h-DRK1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: KCNB1; Polyclonal Antibody; KCNB1 Polyclonal Antibody; DRK1; KV2.1; h-DRK1; anti-KCNB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.9mg/mL (varies by lot)
• Sequence Length: 813

• Applicable Applications for anti-KCNB1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human KCNB1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using KCNB1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using KCNB1 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-KCNB1 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.

NCBI and Uniprot Product Information

• NCBI GI #: 84570020
• NCBI GeneID: 3745
• Molecular Weight: 95,878 Da
• NCBI Official Full Name: KCNB1 protein, partial
• NCBI Official Synonym Full Names: potassium channel, voltage gated Shab related subfamily B, member 1
• NCBI Official Symbol: KCNB1
• NCBI Official Synonym Symbols: DRK1; KV2.1; EIEE26; h-DRK1
• NCBI Protein Information: potassium voltage-gated channel subfamily B member 1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; h-DRK1 K(+) channel; potassium channel protein DRK1; potassium voltage-gated channel, Shab-related subfamily, member 1; voltage-gated potassium channel subunit Kv2.1
• UniProt Protein Name: Potassium voltage-gated channel subfamily B member 1
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNB1
• UniProt Synonym Gene Names: DRK1; h-DRK1
• UniProt Entry Name: KCNB1_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.

Protein type: Membrane protein, multi-pass; Channel, potassium; Channel, cation; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membrane

Molecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus binding

Biological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Epileptic Encephalopathy, Early Infantile, 26