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Western Blot (WB) (Western blot analysis of extracts from K562 cells treated with TNF using Phospho-Kv2.1 (Ser805) antibody.The lane on the right is treated with the antigen-specific peptide.)

Rabbit anti-Human Kv2.1 Polyclonal Antibody | anti-Kv2.1 antibody

Kv2.1 (Phospho-Ser805) Antibody

Gene Names
KCNB1; DRK1; KV2.1; EIEE26; h-DRK1
Reactivity
Human
Applications
Western Blot
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Synonyms
Kv2.1; Polyclonal Antibody; Kv2.1 (Phospho-Ser805) Antibody; DRK1; KCB1; KCNB1; Potassium channel Kv2.1; Potassium voltage-gated channel subfamily B member 1; anti-Kv2.1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous level of Kv2.1 only when phosphorylated at serine 805.
Purity/Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
858
Applicable Applications for anti-Kv2.1 antibody
Western Blot (WB)
Application Notes
Western blotting: 1:500~1:1000
Immunogen Type
Peptide-KLH
Immunogen Description
Peptide sequence around phosphorylation site of serine805(P-T-S(p)-P-K) derived from Human Kv2.1.
Modification
Phospho-Ser805
Target Name
Kv2.1
Preparation and Storage
Store at -20 degree C/1 year

Western Blot (WB)

(Western blot analysis of extracts from K562 cells treated with TNF using Phospho-Kv2.1 (Ser805) antibody.The lane on the right is treated with the antigen-specific peptide.)

Western Blot (WB) (Western blot analysis of extracts from K562 cells treated with TNF using Phospho-Kv2.1 (Ser805) antibody.The lane on the right is treated with the antigen-specific peptide.)
Related Product Information for anti-Kv2.1 antibody
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.McCord MC, Aizenman E (2013)Proc Natl Acad Sci U S A 110, 13988-93. Norris CA, et al. (2012) J Neurosci 32, 8865-70. Cerda O, Trimmer JS (2011)J Biol Chem 286, 28738-48.
Product Categories/Family for anti-Kv2.1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
95,878 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily B member 1
NCBI Official Synonym Full Names
potassium channel, voltage gated Shab related subfamily B, member 1
NCBI Official Symbol
KCNB1
NCBI Official Synonym Symbols
DRK1; KV2.1; EIEE26; h-DRK1
NCBI Protein Information
potassium voltage-gated channel subfamily B member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily B member 1
UniProt Gene Name
KCNB1
UniProt Synonym Gene Names
h-DRK1
UniProt Entry Name
KCNB1_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.

Protein type: Channel, potassium; Channel, cation; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; integral to membrane; plasma membrane

Molecular Function: protein binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein N-terminus binding

Biological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Epileptic Encephalopathy, Early Infantile, 26

Research Articles on Kv2.1

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Product Notes

The Kv2.1 kcnb1 (Catalog #AAA9409159) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Kv2.1 (Phospho-Ser805) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Kv2.1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:1000. Researchers should empirically determine the suitability of the Kv2.1 kcnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kv2.1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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