Goat KCNB1 Polyclonal Antibody | anti-KCNB1 antibody

KCNB1 (DRK1, Potassium voltage-gated channel, Shab-related subfamily, member 1, DRK1, KV2.1, h-DRK1, delayed rectifier potassium channel Kv2.1)

Cat. Num. AAA620917

• Gene Names: KCNB1; DRK1; KV2.1; h-DRK1
• Reactivity: Bovine, Canine, Human, Mouse, Porcine
• Applications: ELISA
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: KCNB1; Polyclonal Antibody; KCNB1 (DRK1; Potassium voltage-gated channel; Shab-related subfamily; member 1; DRK1; KV2.1; h-DRK1; delayed rectifier potassium channel Kv2.1); Anti -KCNB1 (DRK1; anti-KCNB1 antibody

• Host: Goat
• Reactivity: Bovine, Canine, Human, Mouse, Porcine
• Clonality: Polyclonal
• Specificity: Recognizes human KCNB1. Species Crossreactivity: mouse, canine, bovine, porcine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-KCNB1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: Peptide ELISA: 1:4,000.; Western Blot: 0.5ug/ml. Preliminary experiments gave a 100kD band and additional stronger bands at approx 50kD and 38kD in Human Brain (Cerebellum) and Heart lysates. Optimal dilutions to be determined by the reseacher.
• Immunogen: A synthetic peptide from the C-terminus of aa--HQYIDADTDDEGQ.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-KCNB1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 84570020
• NCBI GeneID: 3745
• UniProt Accession #: Q2NLD5; Q14721
• Molecular Weight: 90,784 Da
• NCBI Official Full Name: KCNB1 protein
• NCBI Official Synonym Full Names: potassium voltage-gated channel, Shab-related subfamily, member 1
• NCBI Official Symbol: KCNB1
• NCBI Official Synonym Symbols: DRK1; KV2.1; h-DRK1
• NCBI Protein Information: potassium voltage-gated channel subfamily B member 1; OTTHUMP00000031697; h-DRK1 K(+) channel; potassium channel protein DRK1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; voltage-gated potassium channel subunit Kv2.1
• UniProt Protein Name: KCNB1 protein
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNB1
• UniProt Entry Name: Q2NLD5_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq]

Uniprot Description

Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Channel, cation; Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; integral to membrane; plasma membrane

Molecular Function: protein binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein N-terminus binding

Biological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Epileptic Encephalopathy, Early Infantile, 26