Western Blot (WB)
(Western blot analysis of Munc13-2 expression in LO2 (A) whole cell lysates.)
Rabbit anti-Human Munc13-2 Polyclonal Antibody | anti-Munc13-2 antibody
Anti-Munc13-2 Antibody
Western Blot (WB)
(Western blot analysis of Munc13-2 expression in LO2 (A) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of Munc13-2 expression in LO2 (A) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
Uniprot Description
UNC13B: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Belongs to the unc-13 family.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: Golgi apparatus; cytoplasm; presynaptic active zone; plasma membrane; terminal button; cell junction; cytosol; neuromuscular junction
Molecular Function: diacylglycerol binding; protein binding; signal transducer activity; metal ion binding; receptor activity
Biological Process: synaptic transmission, glutamatergic; synaptic transmission; glutamate secretion; apoptosis; neurotransmitter secretion; regulation of short-term neuronal synaptic plasticity; excretion; signal transduction; synaptic vesicle priming; neuromuscular junction development; synaptic vesicle docking during exocytosis
Research Articles on Munc13-2
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Product Notes
The Munc13-2 unc13b (Catalog #AAA8308561) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Munc13-2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Munc13-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the Munc13-2 unc13b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Munc13-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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