Rabbit anti-Human KCNAB1 Polyclonal Antibody | anti-KCNAB1 antibody

KCNAB1, NT (KCNAB1, KCNA1B, Voltage-gated potassium channel subunit beta-1, K(+) channel subunit beta-1, Kv-beta-1)

Cat. Num. AAA6009207

• Gene Names: KCNAB1; Kvbeta1.1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: KCNAB1; Polyclonal Antibody; NT (KCNAB1; KCNA1B; Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1); Anti -KCNAB1; anti-KCNAB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-KCNAB1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: KCNAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human KCNAB1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNAB1 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the KCNAB1 antibody detected the KCNAB1 protein (arrow).)

Related Product Information for anti-KCNAB1 antibody

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.

Product Categories/Family for anti-KCNAB1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 151555828
• NCBI GeneID: 526133
• UniProt Accession #: Q4PJK1; Q05B86
• Molecular Weight: 44,710 Da
• NCBI Official Full Name: KCNAB1 protein
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, beta member 1<
• NCBI Official Symbol: KCNAB1
• NCBI Official Synonym Symbols: Kvbeta1.1
• NCBI Protein Information: voltage-gated potassium channel subunit beta-1; kv-beta-1; K(+) channel subunit beta-1; potassium voltage-gated channel shaker-related subfamily beta member 1
• UniProt Protein Name: Voltage-gated potassium channel subunit beta-1
• Protein Family: Voltage-gated potassium channel
• UniProt Gene Name: KCNAB1
• UniProt Entry Name: KCAB1_BOVIN

Uniprot Description

Function: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alter the functional properties of Kv1.1 and Kv1.4

By similarity.

Subunit structure: Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1

By similarity. Part of a complex containing KCNA1, KCNA4 and LGI1

By similarity.

Subcellular location: Cytoplasm

Potential.

Domain: Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit

Probable.

Sequence similarities: Belongs to the shaker potassium channel beta subunit family.