Rabbit KANK2 Polyclonal Antibody | anti-KANK2 antibody

KANK2 Polyclonal Antibody

Cat. Num. AAA3007373

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KANK2; Polyclonal Antibody; KANK2 Polyclonal Antibody; KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein; ANKRD25; KIAA1518; MXRA3; anti-KANK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KANK2 polyclonal antibody detects endogenous levels of KANK2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 851

• Applicable Applications for anti-KANK2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 340-385 of Human KANK2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of KANK2 polyclonal antibody at 1:1000 dilutionLane1:HELA whole cell lysate (51. 3ug) Lane2:The Uterus tissue lysate of Rat (43. 4ug) Lane3:The Uterus tissue lysate of Mouse (37. 4ug) Lane4:The Heart tissue lysate of Rat (43. 4ug) Lane5:The Heart tissue lysate of Mouse (37. 4ug))

Related Product Information for anti-KANK2 antibody

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed: 24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed: 22371500). May be involved in promotion of cell proliferation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 209969812
• NCBI Accession #: NP_001129663.1
• NCBI GenBank Nucleotide #: NP_001129663.1
• UniProt Accession #: Q63ZY3
• Molecular Weight: ~ 117kDa
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 2 isoform 2
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK2
• UniProt Synonym Gene Names: ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein
• UniProt Entry Name: KANK2_HUMAN

Uniprot Description

ANKRD25: a mammalian growth regulatory protein containing five Ankyrin repeats, common protein-protein interaction motifs. Ankyrin repeats are found in proteins with diverse functions including transcriptional initiators, cell-cycle regulators, cytoskeletal, and ion transporters. Three alternatively spliced isoforms have been described.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: mitochondrion; cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; apoptosis; negative regulation of programmed cell death; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway

Disease: Palmoplantar Keratoderma And Woolly Hair