Western Blot (WB)
(Anti- gamma Catenin Picoband antibody, MBS177507, Western blottingAll lanes: Anti gamma Catenin(MBS177507) at 0.5ug/mlWB: Recombinant Human gamma Catenin Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Rabbit Junction plakoglobin Polyclonal Antibody | anti-JUP antibody
Anti-gamma Catenin Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat
Immunohistochemistry (Frozen Section): Concentration: 0.5-1mug/ml; Tested Species: Rat; Predicted Species: Human
Western Blot (WB)
(Anti- gamma Catenin Picoband antibody, MBS177507, Western blottingAll lanes: Anti gamma Catenin(MBS177507) at 0.5ug/mlWB: Recombinant Human gamma Catenin Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Western Blot (WB)
(Anti- gamma Catenin Picoband antibody, MBS177507, Western blottingAll lanes: Anti gamma Catenin(MBS177507) at 0.5ug/mlWB: Recombinant Human gamma Catenin Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Western Blot (WB)
(Anti- gamma Catenin Picoband antibody, MBS177507, Western blottingAll lanes: Anti gamma Catenin (MBS177507) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Rat Cardiac Muscle Tissue Lysate at 50ugLane 3: Rat Thymus Tissue Lysate at 50ugLane 4: RH35 Whole Cell Lysate at 40ugLane 5: Hela Whole Cell Lysate at 40ugLane 6: Colo320 Whole Cell Lysate at 40ugLane 7: HepG2 Whole Cell Lysate at 40ugLane 8: HepA Whole Cell Lysate at 40ugLane 9: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 81KD Observed bind size: 81KD)
Western Blot (WB)
(Anti- gamma Catenin Picoband antibody, MBS177507, Western blottingAll lanes: Anti gamma Catenin (MBS177507) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Rat Cardiac Muscle Tissue Lysate at 50ugLane 3: Rat Thymus Tissue Lysate at 50ugLane 4: RH35 Whole Cell Lysate at 40ugLane 5: Hela Whole Cell Lysate at 40ugLane 6: Colo320 Whole Cell Lysate at 40ugLane 7: HepG2 Whole Cell Lysate at 40ugLane 8: HepA Whole Cell Lysate at 40ugLane 9: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 81KD Observed bind size: 81KD)
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(P)IHC(P): Mouse Intestine Tissue )
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(P)IHC(P): Mouse Intestine Tissue )
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(P)IHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(P)IHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(F)IHC(F): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti- gamma Catenin Picoband antibody, MBS177507, IHC(F)IHC(F): Rat Intestine Tissue )
Background: Junction plakoglobin(JUP), also known as gamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin, and it is mapped to 17q21.2. This gene encodes a major cytoplasmic protein that is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins. Meanwhile, JUP may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Uniprot Description
CTNNG: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: desmosome; internal side of plasma membrane; focal adhesion; apicolateral plasma membrane; intermediate filament; catenin complex; intercellular junction; zonula adherens; fascia adherens; Z disc; cytosol; actin cytoskeleton; cell-cell adherens junction; cytoskeleton; hemidesmosome; cytoplasm; plasma membrane; nucleus; lateral plasma membrane
Molecular Function: protein binding; signal transducer activity; protein homodimerization activity; structural constituent of cell wall; cadherin binding; transcription coactivator activity; structural molecule activity; protein phosphatase binding; protein kinase binding; alpha-catenin binding; nuclear hormone receptor binding
Biological Process: skin development; intercellular junction assembly and maintenance; cell-cell adhesion; cell migration; positive regulation of protein import into nucleus; protein heterooligomerization; cytoskeletal anchoring; regulation of cell fate specification; detection of mechanical stimulus; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway; regulation of cell proliferation
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease
Research Articles on JUP
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Product Notes
The JUP jup (Catalog #AAA177507) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-gamma Catenin Antibody reacts with Human, Mouse, Rat. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Junction plakoglobin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-F). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat Immunohistochemistry (Frozen Section): Concentration: 0.5-1mug/ml; Tested Species: Rat; Predicted Species: Human. Researchers should empirically determine the suitability of the JUP jup for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Junction plakoglobin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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