Western Blot (WB)
(Western blot analysis of JIP4 expression in HEK293T (A), Raw264.7 (B), SP2/0 (C) whole cell lysates.)
Rabbit JIP4 Polyclonal Antibody | anti-SPAG9 antibody
Anti-JIP4 Antibody
Western Blot (WB)
(Western blot analysis of JIP4 expression in HEK293T (A), Raw264.7 (B), SP2/0 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of JIP4 expression in HEK293T (A), Raw264.7 (B), SP2/0 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Uniprot Description
JIP4: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1. Isoform 3 is increased in systemic sclerosis fibroblasts. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. Belongs to the JIP scaffold family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: perinuclear region of cytoplasm; cytoplasm; integral to membrane; acrosome; cytosol
Molecular Function: JUN kinase binding; protein binding; MAP-kinase scaffold activity; mitogen-activated protein kinase p38 binding; receptor signaling complex scaffold activity; kinesin binding
Biological Process: muscle cell differentiation; positive regulation of muscle cell differentiation; striated muscle cell differentiation; spermatogenesis; positive regulation of neuron differentiation; retrograde transport, endosome to Golgi; activation of JNK activity; protein homooligomerization; positive regulation of cell migration
Research Articles on SPAG9
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Product Notes
The SPAG9 spag9 (Catalog #AAA821908) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-JIP4 Antibody reacts with Human, Mouse, Rat, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's JIP4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the SPAG9 spag9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JIP4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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