Rabbit anti-Mouse GRIN2C Polyclonal Antibody | anti-GRIN2C antibody

GRIN2C, ID (GRIN2C, NMDAR2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C) (MaxLight 650)

Cat. Num. AAA6304445

• Gene Names: GRIN2C; NR2C; GluN2C; NMDAR2C
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: GRIN2C; Polyclonal Antibody; ID (GRIN2C; NMDAR2C; Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C) (MaxLight 650); N-methyl D-aspartate receptor subtype 2C; anti-GRIN2C antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse GRIN2C.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-GRIN2C antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 567-595 in the central region of human GRIN2C, UniProt Accession #Q14957.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of MBS6000018 in mouse cerebellum tissue lysates (35ug/lane). This demonstrates that MBS6000018 detected the GRIN2C protein (arrow).)

Related Product Information for anti-GRIN2C antibody

MaxLight650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor647, DyLight649, Cy5 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.

Product Categories/Family for anti-GRIN2C antibody

Antibodies; Ion Channel

References

1. Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009). 2. Tabakoff, B., et al. BMC Biol. 7, 70 (2009). 3. Shi, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (7), 1270-1277 (2008). 4. Self, R.L., et al. Brain Res. 995(1):39-45(2004). 5. Krapivinsky, G., et al. Neuron 40(4):775-784(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 55770854
• NCBI GeneID: 2905
• NCBI Accession #: NP_000826.2
• NCBI GenBank Nucleotide #: NM_000835.4
• UniProt Accession #: Q14957; B2RTT1
• Molecular Weight: 134,209 Da
• NCBI Official Full Name: glutamate receptor ionotropic, NMDA 2C isoform 1
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, N-methyl D-aspartate 2C
• NCBI Official Symbol: GRIN2C
• NCBI Official Synonym Symbols: NR2C; GluN2C; NMDAR2C
• NCBI Protein Information: glutamate receptor ionotropic, NMDA 2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; glutamate [NMDA] receptor subunit epsilon-3
• UniProt Protein Name: Glutamate receptor ionotropic, NMDA 2C
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: GRIN2C
• UniProt Synonym Gene Names: NMDAR2C; GluN2C; NMDAR2C; NR2C
• UniProt Entry Name: NMDE3_HUMAN

NCBI Description

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: postsynaptic membrane; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein N-terminus binding; cation channel activity; PDZ domain binding

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; protein localization; transport; directional locomotion; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; response to wounding; regulation of excitatory postsynaptic membrane potential; neuromuscular process controlling balance; negative regulation of protein catabolic process