Rabbit anti-Human, Mouse ITGB1BP1 Polyclonal Antibody | anti-ITGB1BP1 antibody

ITGB1BP1 Polyclonal Antibody

Cat. Num. AAA2562979

• Gene Names: ITGB1BP1; ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: ITGB1BP1; Polyclonal Antibody; ITGB1BP1 Polyclonal Antibody; Bodenin; DKFZp686K08158; ICAP 1; ICAP 1A; ICAP 1alpha; ICAP 1B; ICAP-1; ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1; ICAP1A; ICAP1B; Integrin beta 1 binding protein 1; Integrin beta-1-binding protein 1; Integrin cytoplasmic domain associated protein 1 alpha; Integrin cytoplasmic domain associated protein 1; Integrin cytoplasmic domain associated protein 1 beta; Integrin cytoplasmic domain-associated protein 1; ITBP1; anti-ITGB1BP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.02mg/mL (varies by lot)
• Sequence Length: 200

• Applicable Applications for anti-ITGB1BP1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human ITGB1BP1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ITGB1BP1 Polyclonal Antibody at dilution of 1:60(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ITGB1BP1 Polyclonal Antibody at dilution of 1:60(×200))

Related Product Information for anti-ITGB1BP1 antibody

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene.

Product Categories/Family for anti-ITGB1BP1 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4758578
• NCBI GeneID: 9270
• NCBI Accession #: NP_004754.1; BC012264
• NCBI GenBank Nucleotide #: NP_004754.1
• UniProt Accession #: O14713
• NCBI Official Full Name: integrin beta-1-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: integrin subunit beta 1 binding protein 1
• NCBI Official Symbol: ITGB1BP1
• NCBI Official Synonym Symbols: ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha
• NCBI Protein Information: integrin beta-1-binding protein 1
• UniProt Protein Name: Integrin beta-1-binding protein 1
• Protein Family: Integrin beta-1-binding protein
• UniProt Gene Name: ITGB1BP1
• UniProt Synonym Gene Names: ICAP1; ICAP-1
• UniProt Entry Name: ITBP1_HUMAN

NCBI Description

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

ICAP1: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p25.2

Cellular Component: ruffle; focal adhesion; cytoskeleton; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: integrin binding; protein binding; GDP-dissociation inhibitor activity; protein complex binding; protein kinase binding; protein transporter activity

Biological Process: integrin activation; cell-matrix adhesion; receptor clustering; negative regulation of cell proliferation; regulation of cell adhesion mediated by integrin; protein transport; positive regulation of focal adhesion formation; biomineral formation; positive regulation of cell proliferation; positive regulation of stress fiber formation; cell differentiation; regulation of blood vessel size; negative regulation of protein binding; positive regulation of Notch signaling pathway; integrin-mediated signaling pathway; Notch signaling pathway; cell migration; substrate-bound cell migration, cell release from substrate; transcription, DNA-dependent; activation of protein kinase B; negative regulation of focal adhesion formation; lumen formation; positive regulation of protein kinase B signaling cascade; blood vessel endothelial cell proliferation during sprouting angiogenesis; positive regulation of cell division; myoblast migration; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter