Rabbit anti-Human ITGAV/Integrin Alpha V/CD51 Polyclonal Antibody | anti-ITGAV antibody

Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51

Cat. Num. AAA244840

• Gene Names: ITGAV; CD51; MSK8; VNRA; VTNR
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: ITGAV/Integrin Alpha V/CD51; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51; Anti-ITGAV/Integrin Alpha V/CD51 Antibody (aa840-889) IHC-plus; ITGAV; CD51; CD51 antigen; Integrin; alpha V; MSK8; Integrin Alpha V; Integrin alpha-V; VNRA; Vitronectin receptor; Integrin alphaVbeta3; VTNR; Human ITGAV/Integrin Alpha V/CD51; anti-ITGAV antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ITGAV (heavy chain,Cleaved-Lys889) Antibody detects endogenous levels of fragment of activated ITGAV resulting from cleavage adjacent to Lys889.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1048

• Applicable Applications for anti-ITGAV antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:10000), IHC-P (5 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human ITGAV (aa840-889).
• Immunogen: ITGAV/Integrin Alpha V/CD51 antibody was raised against synthetic peptide from human ITGAV (aa840-889).
• Antigen Modification: aa840-889
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-CD51 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-CD51 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of extracts from A549 cells, treated with etoposide 25 uM 1h, using ITGAV (heavy chain, Cleaved-Lys889) Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-ITGAV antibody

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins.

Product Categories/Family for anti-ITGAV antibody

Family: Integrin

NCBI and Uniprot Product Information

• NCBI GI #: 4504763
• NCBI GeneID: 3685
• NCBI Accession #: NP_002201.1
• NCBI GenBank Nucleotide #: NM_002210.4
• UniProt Accession #: P06756; Q53SK4; Q59EB7; Q6LD15; A0AV67; B0LPF4; B7Z883; B7ZLX0; D3DPG8; E7EWZ6
• Molecular Weight: 111,132 Da
• NCBI Official Full Name: integrin alpha-V isoform 1
• NCBI Official Synonym Full Names: integrin, alpha V
• NCBI Official Symbol: ITGAV
• NCBI Official Synonym Symbols: CD51; MSK8; VNRA; VTNR
• NCBI Protein Information: integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
• UniProt Protein Name: Integrin alpha-V
• Protein Family: Integrin
• UniProt Gene Name: ITGAV
• UniProt Synonym Gene Names: MSK8; VNRA
• UniProt Entry Name: ITAV_HUMAN

NCBI Description

This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]

Uniprot Description

ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q31-q32

Cellular Component: filopodium membrane; focal adhesion; cell surface; membrane; integral to plasma membrane; microvillus membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane

Molecular Function: viral receptor activity; voltage-gated calcium channel activity; protein binding; opsonin binding; insulin-like growth factor I binding; protease binding; protein kinase C binding; extracellular matrix binding; transforming growth factor beta binding; metal ion binding; fibronectin binding

Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; positive regulation of cell adhesion; cell-matrix adhesion; negative chemotaxis; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; cell growth; cell adhesion; integrin-mediated signaling pathway; cell migration; negative regulation of lipoprotein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-substrate adhesion; heterotypic cell-cell adhesion; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; blood coagulation; vascular endothelial growth factor receptor signaling pathway; leukocyte migration; apoptotic cell clearance; positive regulation of cell migration