Western Blot (WB)
(Western blot analysis of extracts of mouse liver with ITGA2B Polyclonal Antibody at dilution of 1:1000)
Rabbit anti-Human, Mouse ITGA2B Polyclonal Antibody | anti-ITGA2B antibody
ITGA2B Antibody
IF: 1:10-1:100
Western Blot (WB)
(Western blot analysis of extracts of mouse liver with ITGA2B Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western blot analysis of extracts of mouse liver with ITGA2B Polyclonal Antibody at dilution of 1:1000)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using ITGA2B Polyclonal Antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using ITGA2B Polyclonal Antibody.)
NCBI and Uniprot Product Information
Observed MW: 135kDa
NCBI Description
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Uniprot Description
ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: platelet alpha granule membrane; cell surface; focal adhesion; integral to plasma membrane; plasma membrane; integrin complex; external side of plasma membrane
Molecular Function: identical protein binding; protein binding; extracellular matrix binding; metal ion binding
Biological Process: integrin-mediated signaling pathway; platelet activation; axon guidance; extracellular matrix organization and biogenesis; platelet degranulation; cell-matrix adhesion; positive regulation of leukocyte migration; cell adhesion; blood coagulation
Disease: Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16
Research Articles on ITGA2B
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Product Notes
The ITGA2B itga2b (Catalog #AAA2521429) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ITGA2B Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ITGA2B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofuorescence (IF). WB: 1:500 - 1:2000 IF: 1:10-1:100. Researchers should empirically determine the suitability of the ITGA2B itga2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ITGA2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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