Rabbit Irisin Polyclonal Antibody | anti-Irisin antibody

Anti-Irisin Antibody

Cat. Num. AAA847331

• Gene Names: FNDC5; FRCP2; irisin
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purified rabbit IgG
• Synonyms: Irisin; Polyclonal Antibody; Anti-Irisin Antibody; Fibronectin Type III Domain-containing Protein 5; FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2; FRCP2 (cleaved); anti-Irisin antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Polyclonal Antibody to detect Irisin in human, mouse and rat samples
• Purity/Purification: Affinity purified rabbit IgG
• Form/Format: Colorless liquid. In PBS pH7.2, containing 30% glycerol, 0.5% BSA, 5mM EDTA and 0.03% Proclin

• Applicable Applications for anti-Irisin antibody: Western Blot (WB)
• Application Notes: WB: 1-4ug
• Immunogen: Human recombinant Irisin
• Positive Control: WB: Rat kidney lysate, Human recombinant Irisin
• Preparation and Storage: Store at -20 degree C; The antibody solution should be gently mixed before use.; Shelf life: ~12 months

Western Blot (WB)

Related Product Information for anti-Irisin antibody

Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.

Product Categories/Family for anti-Irisin antibody

Immunology; Antibodies & Supporting Tools; Trial Size Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 511093995
• NCBI GeneID: 252995
• NCBI Accession #: NP_001165411.2
• NCBI GenBank Nucleotide #: NM_001171940.1
• UniProt Accession #: Q8NAU1; Q6P6D9; Q7Z676; A6NMC9; D3DPQ6
• Molecular Weight: 15,527 Da
• NCBI Official Full Name: fibronectin type III domain-containing protein 5 isoform 3 preproprotein
• NCBI Official Synonym Full Names: fibronectin type III domain containing 5
• NCBI Official Symbol: FNDC5
• NCBI Official Synonym Symbols: FRCP2; irisin
• NCBI Protein Information: fibronectin type III domain-containing protein 5; fibronectin type III repeat-containing protein 2
• UniProt Protein Name: Fibronectin type III domain-containing protein 5
• UniProt Gene Name: FNDC5
• UniProt Synonym Gene Names: FRCP2
• UniProt Entry Name: FNDC5_HUMAN

NCBI Description

This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

FNDC5: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: peroxisomal membrane; endoplasmic reticulum; plasma membrane; integral to membrane; extracellular region

Molecular Function: hormone activity

Biological Process: response to muscle activity