Rabbit anti-Human IQSEC2 Polyclonal Antibody | anti-IQSEC2 antibody

IQSEC2 (IQ Motif and SEC7 Domain-Containing Protein 2, IQSEC2, KIAA0522) (MaxLight 550)

Cat. Num. AAA6456697

• Gene Names: IQSEC2; MRX1; BRAG1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IQSEC2; Polyclonal Antibody; IQSEC2 (IQ Motif and SEC7 Domain-Containing Protein 2; KIAA0522) (MaxLight 550); anti-IQSEC2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IQSEC2. Species Crossreactivity: human
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-IQSEC2 antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa451-484 at the Central region of human IQSEC2.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-IQSEC2 antibody

Antibodies; KIAA; orf

References

Nagase T., et al. DNA Res. 5:31-39(1998). Ota T., et al. Nat. Genet. 36:40-45(2004). Ross M.T., et al. Nature 434:325-337(2005). Shapovalova Z., et al. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases. Rigbolt K.T., et al. Sci. Signal. 4:RS3-RS3(2011).

NCBI and Uniprot Product Information

• NCBI GI #: 162138911
• NCBI GeneID: 23096
• NCBI Accession #: NP_001104595
• NCBI GenBank Nucleotide #: NM_001111125.2
• UniProt Accession #: Q5JU85; O60275; Q5JUX1; B3KT97; C7SDG1
• Molecular Weight: Predicted: 104; 133; 141; 164 kDa; ; Observed: 140 kDa
• NCBI Official Full Name: IQ motif and SEC7 domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: IQ motif and Sec7 domain 2
• NCBI Official Symbol: IQSEC2
• NCBI Official Synonym Symbols: MRX1; BRAG1
• NCBI Protein Information: IQ motif and SEC7 domain-containing protein 2; brefeldin A resistant Arf-guanine nucleotide exchange factor 1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1b; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c
• UniProt Protein Name: IQ motif and SEC7 domain-containing protein 2
• Protein Family: IQ motif and SEC7 domain-containing protein
• UniProt Gene Name: IQSEC2
• UniProt Synonym Gene Names: KIAA0522
• UniProt Entry Name: IQEC2_HUMAN

NCBI Description

This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

IQSEC2: Defects in IQSEC2 are the cause of mental retardation X- linked type 1 (MRX1). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. Belongs to the BRAG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, ARF; GEFs

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: trans-Golgi network; cell junction; nucleus

Molecular Function: ARF guanyl-nucleotide exchange factor activity

Biological Process: vesicle-mediated transport; regulation of ARF protein signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity

Disease: Mental Retardation, X-linked 1