Rabbit anti-Human IPO8 Polyclonal Antibody | anti-IPO8 antibody

IPO8 Antibody

Cat. Num. AAA9401088

• Gene Names: IPO8; RANBP8
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: IPO8; Polyclonal Antibody; IPO8 Antibody; RANBP8; anti-IPO8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total IPO8 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.4 mg/ml (varies by lot)
• Sequence Length: 832

• Applicable Applications for anti-IPO8 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:100-1:300
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human importin 8
• Target Name: IPO8
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/50.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/50.)

Related Product Information for anti-IPO8 antibody

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-IPO8 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 300360505
• NCBI GeneID: 10526
• NCBI Accession #: NP_001177924.1
• NCBI GenBank Nucleotide #: NM_001190995.1
• UniProt Accession #: O15397; B7Z7M3
• Molecular Weight: 96,036 Da
• NCBI Official Full Name: importin-8 isoform 2
• NCBI Official Synonym Full Names: importin 8
• NCBI Official Symbol: IPO8
• NCBI Official Synonym Symbols: RANBP8
• NCBI Protein Information: importin-8
• UniProt Protein Name: Importin-8
• Protein Family: Importin
• UniProt Gene Name: IPO8
• UniProt Synonym Gene Names: RANBP8; Imp8; RanBP8
• UniProt Entry Name: IPO8_HUMAN

NCBI Description

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

IPO8: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Karyopherin; Nuclear import; G protein regulator, misc.; Nuclear export

Chromosomal Location of Human Ortholog: 12p11.21

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein binding; Ran GTPase binding

Biological Process: intracellular protein transport; gene expression; signal transduction