Rabbit anti-Mouse Interleukin 8 Receptor Beta (IL8Rb) Polyclonal Antibody | anti-IL8Rb antibody
Polyclonal Antibody to Interleukin 8 Receptor Beta (IL8Rb)
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
NCBI and Uniprot Product Information
Uniprot Description
IL8RB: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1 C3|1 38.41 cM
Cellular Component: cell surface; integral component of membrane; intracellular; mast cell granule; membrane; plasma membrane
Molecular Function: C-X-C chemokine receptor activity; chemokine receptor activity; G-protein coupled receptor activity; interleukin-8 binding; interleukin-8 receptor activity; protein binding; signal transducer activity
Biological Process: acute inflammatory response to antigenic stimulus; cell surface receptor signaling pathway; cellular defense response; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; metanephric tubule morphogenesis; negative regulation of apoptosis; negative regulation of neutrophil apoptosis; neutrophil activation; neutrophil chemotaxis; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cell proliferation; positive regulation of leukocyte chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of vascular permeability; receptor internalization; signal transduction
Research Articles on IL8Rb
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Product Notes
The IL8Rb cxcr2 (Catalog #AAA2007271) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Interleukin 8 Receptor Beta (IL8Rb) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin 8 Receptor Beta (IL8Rb) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the IL8Rb cxcr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 8 Receptor Beta (IL8Rb), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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