Western Blot (WB)
Rabbit anti-Human Interleukin-7 receptor alpha, IL-7Ralpha / CD127 Polyclonal Antibody | anti-IL-7Ralpha / CD127 antibody
Anti-Interleukin-7 receptor alpha, IL-7Ralpha / CD127 antibody
Reactivity
Human
Applications
Western Blot, Immunocytochemistry
Purity
Immunogen affinity purified
Synonyms
Interleukin-7 receptor alpha; IL-7Ralpha / CD127; Polyclonal Antibody; Anti-Interleukin-7 receptor alpha; IL-7Ralpha / CD127 antibody; Polyclonal Anti- Interleukin-7 receptor alpha; Polyclonal Anti- Interleukin-7 receptor a; IL-7Ra / CD127; anti-IL-7Ralpha / CD127 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified
Form/Format
Liquid
Applicable Applications for anti-IL-7Ralpha / CD127 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
WB (1:1000-5000); ICC (1:100-500)
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of human IL-7Ra.
Storage Buffer
In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide
Preparation and Storage
Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-IL-7Ralpha / CD127 antibody
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-alpha (CD127) and common-gamma chain receptor (CD132).1,2 IL7Ralphais required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency.3 The partial deficiency of IL-7R alpha results in an arrest of T-cell development, leading to typical severe combined immunodeficiency. It has the critical role of IL-7R alpha chain in the differentiation of T cells.4
References
1. Noguchi M, Nakamura Y, Russell SM, et al. (1994). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.". Science 262 (5141): 1877-80. 2. Kroemer RT, Richards WG (1997). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135-42. 3. Shochat, C., Tal, N., Bandapalli, O. R., Palmi, C., Ganmore, I., Kronnie, G., Cario, G., Cazzaniga, G., Kulozik, A. E., Stanulla, M., Schrappe, M., Biondi, A., Basso, G., Bercovich, D., Muckenthaler, M. U., Izraeli, S. Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. J. Exp. Med. 208: 901-908, 2011. 4. Roifman, C. M., Zhang, J., Chitayat, D., Sharfe, N. A partial deficiency of interleukin-7R-alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. Blood 96: 2803-2807, 2000.
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Product Notes
The IL-7Ralpha / CD127 (Catalog #AAA355127) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Interleukin-7 receptor alpha, IL-7Ralpha / CD127 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin-7 receptor alpha, IL-7Ralpha / CD127 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). WB (1:1000-5000); ICC (1:100-500). Researchers should empirically determine the suitability of the IL-7Ralpha / CD127 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin-7 receptor alpha, IL-7Ralpha / CD127, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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